2024
Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study.
Nellis M, Chegondi M, Willems A, Alqatani M, McMichael A, Aran A, Lerner R, Karam O. Assessing the Reliability of the Bleeding Assessment Scale in Critically Ill Children (BASIC) Definition: A Prospective Cohort Study. Pediatric Critical Care Medicine 2024 PMID: 39560732, DOI: 10.1097/pcc.0000000000003638.Peer-Reviewed Original ResearchCritically ill childrenAssessment ScaleIll ChildrenBleeding severityIntra-rater reliabilityInter-rater reliabilityCohort of critically ill childrenChildren aged 0Prospective cohort studyAssociated with increased 28-day mortalityEvaluation of bleedingActivated partial thromboplastin timeBedside nursesPatient demographic dataPartial thromboplastin timeTransfused blood componentsLonger hospital lengthParticipating PICUsCohort studyHemostatic medicationsDiverse cohortInotropic supportBleeding eventsSevere bleedingPlatelet countExecutive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*
Alexander P, Bembea M, Cashen K, Cheifetz I, Dalton H, Himebauch A, Karam O, Moynihan K, Nellis M, Ozment C, Raman L, Rintoul N, Said A, Saini A, Steiner M, Thiagarajan R, Watt K, Willems A, Zantek N, Barbaro R, Steffen K, Vogel A, Almond C, Anders M, Annich G, Brandão L, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli S, Garcia A, Haileselassie B, Hyslop R, Kneyber M, Kreuziger L, Le J, Loftis L, McMichael A, McMullan D, Monagle P, Nicol K, Paden M, Patregnani J, Priest J, Raffini L, Ryerson L, Sloan S, Teruya J, Yates A, Gehred A, Lyman E, Muszynski J, in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators Network T. Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference*. Pediatric Critical Care Medicine 2024, 25: 643-675. PMID: 38959353, PMCID: PMC11216385, DOI: 10.1097/pcc.0000000000003480.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCritically ill childrenClinical managementClinical management of neonatesManaging extracorporeal membrane oxygenationConsensus statementExpert-based statementsIll childrenCochrane Library (CENTRALManagement of neonatesManagement of anticoagulationCochrane Library databasesExpert consensus statementSystematic reviewPractice statementsMembrane oxygenationNonprocedural bleedingClinical trialsLibrary databasesConsensus conferencePerioperative careRecommendations AssessmentAnticoagulationClinical careGeneral careClinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia.
Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 2676591241247981. PMID: 38626382, DOI: 10.1177/02676591241247981.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationExtracorporeal membrane oxygenation daysCritically ill childrenSevere thrombocytopeniaPlatelet countPlatelet transfusionsMembrane oxygenationIll childrenMortality rateDuration of extracorporeal membrane oxygenationAssociated with in-hospital mortality ratesExtracorporeal membrane oxygenation durationSingle-center retrospective studyPlatelet transfusion strategyFrequent platelet transfusionsIn-hospital mortality rateAssociated with bleedingTransfusion strategyAssociated with higher proportionsMedian weightMulticenter studyRetrospective studyClinical outcomesOn-ECMOThrombocytopenia
2023
Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis
Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.Peer-Reviewed Original ResearchContinuous renal replacement therapyExtracorporeal membrane oxygenationMolecular adsorbent recirculating systemRenal replacement therapyHypotensive eventsCircuit lifespanReplacement therapyAnticoagulation strategiesMeta-analysisThrombotic eventsExtracorporeal supportSystematic reviewAssociated with fewer bleeding eventsControl seriesProportion of bleedingMortality rateCritically ill childrenCritically ill patientsStatistically significant decreaseMultiple electronic databasesRandomized controlled trialsRisk of biasBleeding eventsMembrane oxygenationSupport modalities