2023
Anticoagulation and hemostasis on extracorporeal membrane oxygenation
Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.Peer-Reviewed Original ResearchConceptsHemostatic transfusionsMembrane oxygenationPlatelet transfusionsProspective randomized trialsOptimal anticoagulation strategyExtracorporeal membrane oxygenationPlatelet transfusion strategyRecent systematic reviewHemostatic changesAnticoagulation strategiesFrequent complicationMost patientsThrombotic complicationsTransfusion strategyRandomized trialsCareful titrationObservational studyTransfusionSystematic reviewAnticoagulationECMOComplicationsBleedingTwo-fold decreaseRisk
2021
Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.Peer-Reviewed Original Research
2020
Overview of Plasma and Platelet Transfusions in Critically Ill Children
Kahn S, Chegondi M, Nellis ME, Karam O. Overview of Plasma and Platelet Transfusions in Critically Ill Children. Frontiers In Pediatrics 2020, 8: 601659. PMID: 33282804, PMCID: PMC7691248, DOI: 10.3389/fped.2020.601659.Peer-Reviewed Original ResearchAnti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudy
2019
Bleeding Scales Applicable to Critically Ill Children: A Systematic Review.
Nellis ME, Levasseur J, Stribling J, Faustino EVS, Zantek ND, Sheth S, Karam O. Bleeding Scales Applicable to Critically Ill Children: A Systematic Review. Pediatric Critical Care Medicine 2019, 20: 603-607. PMID: 30925573, DOI: 10.1097/pcc.0000000000001943.Peer-Reviewed Original ResearchConceptsIll childrenIdiopathic thrombocytopenic purpuraFull-text articlesBleeding scoreBleeding scaleClinical outcomesIll patientsThrombocytopenic purpuraOvid EmbaseCochrane LibraryDatabase inceptionOvid MEDLINEElectronic searchUnique citationsSystematic reviewFinal reviewClinical measurementsOutpatientsInpatientsChildrenAdultsOutcomesBleedingPurpuraHemorrhageCriteria for Clinically Relevant Bleeding in Critically Ill Children
Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.Peer-Reviewed Original ResearchConceptsRelevant bleedingStreaks of bloodIll childrenEndotracheal tubeClinical relevancePediatric critical care physiciansClinically Relevant BleedingML/Critical care physiciansCritical illnessIll adultsOrgan failureCare physiciansGastric tubeClinical significanceNurse practitionersBleedingDiagnostic criteriaClinical practiceResponse rateIntensivists' perceptionWeb-based surveyDiagnostic definitionRespondents' geographical locationBlood
2018
Platelet Transfusion Practices in Critically Ill Children
Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsCells/LMajor bleedingProphylactic transfusionICU mortalityMinor bleedingIll childrenOverall ICU mortalityPediatric critical illnessPlatelet transfusion practicesProspective cohort studyProphylactic platelet transfusionsCohort studyCritical illnessPost transfusionAdjusted analysisPlatelet countTransfusion practiceAppropriate indicationsMedian changePlatelet doseTransfusionBleedingCells/L.Prophylaxis
2017
Factors influencing plasma transfusion practices in paediatric intensive care units around the world
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.Peer-Reviewed Original ResearchConceptsPlasma transfusion practicesPlasma transfusionTransfusion practiceCoagulation testsPediatric intensive care unitInternational pediatric studiesLocal transfusion serviceAbnormal coagulation testsIntensive care unitEfficacy of transfusionSignificant relevant factorTransfusion policyTransfusion rateCare unitAppropriate indicationsPediatric studiesFrequent treatmentTransfusionResponse rateTransfusion servicesLocal investigatorsPatientsCenter characteristicsWide variationBleeding
2014
Transfusions de plasma en réanimation pédiatrique
Labarinas S, Arni D, Karam O. Transfusions de plasma en réanimation pédiatrique. Médecine Intensive Réanimation 2014, 23: 455-462. DOI: 10.1007/s13546-014-0900-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAbnormal coagulation testsPlasma transfusionCoagulation testsRed blood cell transfusionNon-bleeding patientsBlood cell transfusionIntensive care unitRecent epidemiological studiesCell transfusionIll adultsIll patientsCare unitRéanimation pédiatriqueFrequent treatmentObservational studyCurrent evidenceEpidemiological studiesTransfusionCoagulation factorsVolume replacementPatientsTreatmentMost expertsIndicationsBleeding
2013
Plasma in the PICU: why and when should we transfuse?
Labarinas S, Arni D, Karam O. Plasma in the PICU: why and when should we transfuse? Annals Of Intensive Care 2013, 3: 16. PMID: 23725411, PMCID: PMC3698065, DOI: 10.1186/2110-5820-3-16.Peer-Reviewed Original ResearchAbnormal coagulation testsPlasma transfusionCoagulation testsRed blood cell transfusionBlood cell transfusionIntensive care unitRecent epidemiological studiesCell transfusionIll adultsIll patientsCare unitFrequent treatmentObservational studyCurrent evidenceEpidemiological studiesCoagulation factorsTransfusionVolume replacementPatientsTreatmentMost expertsIndicationsPICUBleedingMorbidity