2015
Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies
de Lanerolle NC, Kim JH, Bandak FA. Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies. Seminars In Neurology 2015, 35: 012-019. PMID: 25714863, DOI: 10.1055/s-0035-1544240.Peer-Reviewed Original ResearchConceptsClosed head injuryTraumatic brain injuryDiffuse axonal injuryAxonal injuryMild TBIHead injuryBrain injurySevere closed head injuryModerate traumatic brain injuryModerate closed head injuryMild traumatic brain injuryAnimal TBI modelsMicroglial activationNeuronal injuryTBI modelCerebral vasculatureInjuryNeuropathologyGross disruptionHuman brainBlunt impactUnique patternHumansActivationAstrocytes
2014
Concussive brain injury from explosive blast
de Lanerolle NC, Hamid H, Kulas J, Pan JW, Czlapinski R, Rinaldi A, Ling G, Bandak FA, Hetherington HP. Concussive brain injury from explosive blast. Annals Of Clinical And Translational Neurology 2014, 1: 692-702. PMID: 25493283, PMCID: PMC4241796, DOI: 10.1002/acn3.98.Peer-Reviewed Original ResearchMild traumatic brain injuryBlast mild traumatic brain injuryPosttraumatic stress disorderMagnetic resonance spectroscopic imagingN-acetyl aspartateBrain injuryMemory impairmentNAA/ChConcussive brain injuryNAA/CrTraumatic brain injuryVariety of symptomsStudy of veteransLarge animal modelHippocampal injuryNeuronal injuryNeuropsychiatric deficitsRight hippocampusMTBI subjectsPosterior hippocampusAnimal modelsHippocampusInjuryStress disorderCognitive Assessment
2010
Astrocytes and Epilepsy
de Lanerolle NC, Lee TS, Spencer DD. Astrocytes and Epilepsy. Neurotherapeutics 2010, 7: 424-438. PMID: 20880506, PMCID: PMC5084304, DOI: 10.1016/j.nurt.2010.08.002.Peer-Reviewed Original ResearchConceptsSeizure focusReactive astrocytesCausation of seizuresGlial fibrillary acidic proteinHippocampal seizure focusRole of astrocytesTemporal lobe epilepsyFibrillary acidic proteinPositive reactive astrocytesNonsclerotic hippocampiHippocampal sclerosisSclerotic hippocampusSubicular neuronsLobe epilepsyEpileptiform activityInflammatory functionsAstrocytesAction potentialsAcidic proteinPotassium ion channelsVascular interfaceEpilepsyHippocampusPrecise roleHuman brain
1999
Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy
Spencer S, Kim J, DeLanerolle N, Spencer D. Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy. Epilepsia 1999, 40: 708-712. PMID: 10368067, DOI: 10.1111/j.1528-1157.1999.tb00767.x.Peer-Reviewed Original ResearchConceptsGlial densityTemporal lobe epilepsyNeuronal densitySpontaneous seizuresLobe epilepsyIctal dischargesSeizure onsetMesial temporal lobe epilepsyElectrical seizure durationHippocampal seizure onsetPercentage of seizuresInterictal-ictal transitionEEG recordingsSeizure durationSeizure parametersPatient's seizuresSeizure propagationPathologic analysisHippocampal fieldsEpilepsy pathogenesisIntracranial EEG recordingsTL resectionSeizuresSynaptic changesPatients
1995
Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy
Luby M, Spencer D, Kim J, deLanerolle N, McCarthy G. Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy. Magnetic Resonance Imaging 1995, 13: 1065-1071. PMID: 8750318, DOI: 10.1016/0730-725x(95)02014-k.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyNeuronal cell lossTemporal lobe epilepsySignificant neuronal cell lossComplete seizure controlMesial temporal sclerosisSeizure controlHippocampal atrophyLobe epilepsyCell lossMagnetic resonance imagingMRI volumetricsMass lesionLoss groupMTS groupTemporal lobeVolumetric atrophyCA fieldsCell countIntractable temporal lobe seizuresMesial temporal sclerosis groupTemporal lobe epilepsy groupAnteromedial temporal lobe resectionGlial cell countsInvasive electrode monitoring
1989
Ultrastructural analysis of axosomatic contacts on functionally identified primate spinothalamic tract neurons
Carlton S, Lamotte C, Honda C, Surmeier D, Delanerolle N, Willis W. Ultrastructural analysis of axosomatic contacts on functionally identified primate spinothalamic tract neurons. The Journal Of Comparative Neurology 1989, 281: 555-566. PMID: 2708581, DOI: 10.1002/cne.902810406.Peer-Reviewed Original ResearchConceptsRound clear vesiclesDense-core vesiclesCell bodiesClear vesiclesSTT cellsLamina VAxosomatic contactsHigh threshold cutaneous afferentsPrimate spinothalamic tract cellsPrimate spinothalamic tract neuronsSpinothalamic tract neuronsSpinothalamic tract cellsSpinelike appendagesUnique innervationRange neuronsTract neuronsCutaneous afferentsTotal populationElectron microscopic levelTerminal typesTract cellsSomatic spinesDendritic treeLateral borderSoma
1987
Corticotroph Cell Pituitary Adenoma Within an Ovarian Teratoma
Axiotis C, Lippes H, Merino M, deLanerolle N, Stewart A, Kinder B. Corticotroph Cell Pituitary Adenoma Within an Ovarian Teratoma. The American Journal Of Surgical Pathology 1987, 11: 218-224. PMID: 3548446, DOI: 10.1097/00000478-198703000-00007.Peer-Reviewed Original ResearchConceptsPituitary adenomasOvarian teratomaBenign cystic ovarian teratomaNormalization of ACTHCareful clinical evaluationBenign cystic teratomaSevere Cushing's syndromeCystic ovarian teratomaLack of suppressionCorticotroph cell adenomasCorticotroph tumor cellsSustained hypercortisolemiaCushing's syndromePituitary massACTH immunoreactivityCystic teratomaOvarian tumorsClinical evaluationCortisol productionTumor massCell adenomaCortisol levelsAdenomasTumor cellsTeratoma
Others
- De Lanerolle, N.C. Lee. T-S. and Spencer, D.D. Histopathology of human epilepsy In: Jasper’s Basic Mechanisms of Epilepsies, 4th Edition (Eds) J.L. Noebels, M. Avoli, M.A. Rogawski, and R.W. Olsen. Chapter 30, p. 387 Oxford University Press, 2012Peer-Reviewed Original Research