2020
Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity
Rottmann D, Assem H, Matsumoto N, Wong S, Hui P, Buza N. Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity. International Journal Of Gynecological Pathology 2020, 40: 263-271. PMID: 32897955, DOI: 10.1097/pgp.0000000000000690.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlgorithmsBiomarkers, TumorBiopsyEndometrial NeoplasmsEndometriumFemaleHumansHysterectomyImmunohistochemistryMiddle AgedReceptor, ErbB-2Sensitivity and SpecificityConceptsEndometrial serous carcinomaDiscordant HER2 statusHER2 immunohistochemical scoresHER2 protein expressionSerous carcinomaHER2 statusEndometrial biopsies/curettingsImmunohistochemical scoreProtein expressionHER2 testingIntratumoral heterogeneityEndometrial biopsy/curettageProlonged progression-free survivalHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2HER2 testing algorithmProgression-free survivalGrowth factor receptor 2HER2-negative tumorsFinal study cohortHER2-positive tumorsRecent clinical trialsSpecimen typesFactor receptor 2Optimal specimen types
2019
Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls
Buza N. Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls. Archives Of Pathology & Laboratory Medicine 2019, 143: 47-64. PMID: 30785337, DOI: 10.5858/arpa.2018-0289-ra.Peer-Reviewed Original ResearchConceptsFrozen section evaluationOvarian epithelial tumorsIntraoperative frozen section evaluationFrozen section diagnosisEpithelial tumorsOvarian tumorsSection evaluationSection diagnosisClear cell ovarian tumorsExtensive staging proceduresExtent of surgeryCareful gross examinationPreoperative diagnostic workupCommon clinical scenariosAccurate frozen section diagnosisSignificant diagnostic challengePotential diagnostic pitfallFrozen section laboratorySurgical stagingStaging procedureYounger patientsBorderline tumorsSerum markersOvarian massesDiagnostic challenge