Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease
Raval NR, Gudmundsen F, Juhl M, Andersen IV, Speth N, Videbæk A, Petersen IN, Mikkelsen JD, Fisher PM, Herth MM, Plavén-Sigray P, Knudsen GM, Palner M. Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Frontiers In Synaptic Neuroscience 2021, 13: 715811. PMID: 34867258, PMCID: PMC8636601, DOI: 10.3389/fnsyn.2021.715811.Peer-Reviewed Original ResearchNeuronal metabolic functionPositron emission tomographyParkinson's diseaseSynaptic densityCortical regionsJ bindingDopaminergic lesionVentral midbrainEmission tomographyIpsilateral ventral midbrainLower synaptic densityRostral substantia nigraUnilateral dopaminergic lesionNon-motor symptomsThalamo-cortical circuitsMetabolic functionsMedial forebrain bundleHigh synaptic densityMedial prefrontal cortexCerebral changesMotor dysfunctionUnilateral injectionDopaminergic neuronsSubstantia nigraBasal ganglia