An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Raval NR, Nasser A, Madsen CA, Beschorner N, Beaman EE, Juhl M, Lehel S, Palner M, Svarer C, Plavén-Sigray P, Jørgensen LM, Knudsen GM. An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates. Frontiers In Neuroscience 2022, 16: 847074. PMID: 35368260, PMCID: PMC8966485, DOI: 10.3389/fnins.2022.847074.Peer-Reviewed Original ResearchPositron emission tomographyNovel radioligandPig modelAlzheimer's diseaseEmission tomographyΑ-synucleinGood translational modelΑ-synuclein pathologyBlood-brain barrierPostmortem human brain tissueReference tissue model 2Gadolinium-enhanced MRILarge animal modelNovel positron emission tomographyHuman brain tissueTimes higher uptakeCerebral injectionLewy bodiesVivo pig modelSaline injectionEssential clinical toolOccipital cortexParkinson's diseaseAppropriate radioligandsPET scans