2024
Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease
Chandran R, Adams T, Kabir I, Gallardo-Vara E, Kaminski N, Gomperts B, Greif D. Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease. Frontiers In Cell And Developmental Biology 2024, 12: 1335061. PMID: 38572485, PMCID: PMC10987733, DOI: 10.3389/fcell.2024.1335061.Peer-Reviewed Original ResearchRNA sequencing analysisSMA+ myofibroblastsGene expression profilesLung myofibroblastsAdult lungSequence analysisResponse to lung injurySingle cell RNA sequencing analysisTissue remodeling genesSmooth muscle cell markersLung to hypoxiaExpression profilesRemodeling genesMuscle cell markersResponse to injuryCell typesSMA cellsLineage tracingLung injuryCell markersLineagesGenesAdult diseaseDrug bleomycinLung surface area
2018
Reconstructing differentiation networks and their regulation from time series single-cell expression data
Ding J, Aronow BJ, Kaminski N, Kitzmiller J, Whitsett JA, Bar-Joseph Z. Reconstructing differentiation networks and their regulation from time series single-cell expression data. Genome Research 2018, 28: 383-395. PMID: 29317474, PMCID: PMC5848617, DOI: 10.1101/gr.225979.117.Peer-Reviewed Original ResearchTranscription factorsSingle-cell expression dataSingle-cell RNA-seq dataRNA-seq dataDiverse cell populationsGene expression levelsDifferent cell typesStages of organogenesisCell fateDescendant cellsDifferentiation networkExpression similarityKey regulatorRegulatory informationExpression dataCell typesProgenitor cellsCell trajectoriesExpression levelsCell populationsDevelopmental dataCellsLineagesOrganogenesisRegulator