2009
Clara Cells Attenuate the Inflammatory Response through Regulation of Macrophage Behavior
Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR. Clara Cells Attenuate the Inflammatory Response through Regulation of Macrophage Behavior. American Journal Of Respiratory Cell And Molecular Biology 2009, 42: 161-171. PMID: 19423773, PMCID: PMC2822978, DOI: 10.1165/rcmb.2008-0353oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseFemaleIn Vitro TechniquesInterleukin-6LipopolysaccharidesLung DiseasesMacrophages, AlveolarMaleMiceMice, CongenicMice, Inbred C57BLMice, KnockoutNeutrophilsOligonucleotide Array Sequence AnalysisPneumoniaRNA, MessengerSignal TransductionToll-Like Receptor 4Tumor Necrosis Factor-alphaUteroglobinConceptsClara cell secretory proteinChronic lung diseaseCell secretory functionWild-type miceInflammatory responseClara cellsLung diseaseEpithelial remodelingGene expression analysisSecretory functionMacrophage behaviorTNF-alpha signalingLung inflammatory responsePolymorphonuclear leukocyte recruitmentTNF-alpha productionExpression analysisSecretory proteinsGenetic mouse modelsPseudomonas aeruginosa LPSPathway modelingCCSP deficiencyLung inflammationExcessive inflammationTNF-alphaAirway fluid
2008
Molecular Staging of Epithelial Maturation Using Secretory Cell–Specific Genes as Markers
Zemke AC, Snyder JC, Brockway BL, Drake JA, Reynolds SD, Kaminski N, Stripp BR. Molecular Staging of Epithelial Maturation Using Secretory Cell–Specific Genes as Markers. American Journal Of Respiratory Cell And Molecular Biology 2008, 40: 340-348. PMID: 18757308, PMCID: PMC2645532, DOI: 10.1165/rcmb.2007-0380oc.Peer-Reviewed Original ResearchConceptsCell-specific genesCategories of genesUnique gene expression profileDevelopmental expression patternsSecretory cellsGene expression profilesCell marker genesExpression of FMO3Messenger RNA abundanceUnique developmental expression patternTransgenic approachesClara cell markerRNA abundanceMarker genesClara cellsExpression patternsExpression profilesMolecular markersEpithelial maturationPhenotypic changesFlavin monooxygenase 3GenesTemporal inductionBronchiolar Clara cellsEmbryonic day