2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2021
Survival of Older Women With Cervical Cancer Based on Screening History.
Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerWomen 50 yearsPrimary care physiciansCervical cancerOverall survivalScreening historyCare physiciansPopulation-level retrospective cohort studyMultivariate analysisHealth care administrative databasesFour-year OSRetrospective cohort studyCervical screening historyUnscreened womenAdvanced diseaseCohort studyScreened groupSurvival benefitImproved survivalCervical screeningKaplan-MeierUnivariate analysisAdministrative databasesOlder womenAge groups
2019
Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing?
Clark M, Lee A, Kupets R. Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing? Journal Of Obstetrics And Gynaecology Canada 2019, 41: 1410-1415. PMID: 30803876, DOI: 10.1016/j.jogc.2018.11.034.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansHealth care encountersCervical cancerCare encountersMore health care encountersRetrospective observational studyCervical cancer screeningHealth care servicesBasis of ageEligible womenCancer screeningAdministrative databasesObservational studyScreening programCare servicesHealth servicesPhysiciansCorrespondence programWomenFurther riskOutreach methodsCancerMailingInfrequent usersPseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer
Seifi F, Parkash V, Clark M, Menderes G, Tierney C, Silasi DA, Azodi M. Pseudovascular Invasion: Minimally Invasive Surgery for Endometrial Cancer. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2019, 23: e2019.00021. PMID: 31285650, PMCID: PMC6596444, DOI: 10.4293/jsls.2019.00021.Peer-Reviewed Original ResearchConceptsLymphovascular space invasionEndometrial cancerSpace invasionEarly-stage endometrial cancerPatients meeting eligibility criteriaInvasive surgical stagingStage endometrial cancerRetrospective cohort studyBody mass indexMeeting eligibility criteriaPeritoneal cytologyAdjuvant radiotherapyAdjuvant therapyAdjuvant treatmentSurgical stagingCohort studyLymphovascular invasionSerous histologyPathologic evaluationMass indexGynecologic pathologistsSubgroup analysisTumor gradeUterine manipulatorIntrauterine manipulator
2015
Transvaginal Morcellation
Donat L, Clark M, Tower AM, Menderes G, Parkash V, Silasi DA, Azodi M. Transvaginal Morcellation. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2015, 19: e2014.00255. PMID: 26005318, PMCID: PMC4432719, DOI: 10.4293/jsls.2014.00255.Peer-Reviewed Original ResearchConceptsTransvaginal morcellationLaparoscopic hysterectomyLeiomyomatous uterusUterine morcellationRobot-assisted laparoscopic hysterectomyLaparoscopic-assisted vaginal hysterectomyCharts of womenLarge uterine specimensMean uterine sizeMean blood lossRetrospective case seriesTotal laparoscopic hysterectomyWedge resection techniqueBaseline demographicsPostoperative outcomesSelect patientsSurgical complicationsBlood lossUterine sizeVaginal hysterectomyCase seriesOperative timeInstitution experienceMalignant entitiesMorcellation technique