2018
Striatal dopamine regulates systemic glucose metabolism in humans and mice
Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Striatal dopamine regulates systemic glucose metabolism in humans and mice. Science Translational Medicine 2018, 10 PMID: 29794060, DOI: 10.1126/scitranslmed.aar3752.Peer-Reviewed Original ResearchConceptsSystemic glucose metabolismDeep brain stimulationPeripheral insulin sensitivityGlucose metabolismInsulin sensitivityStriatal dopamineBilateral deep brain stimulationStriatal neuronal activityPeripheral glucose metabolismReceptor-expressing neuronsStriatal dopamine signalingObservational human studiesNondiabetic patientsInsulin requirementsDopamine depletionGlucose toleranceObsessive-compulsive disorderDiabetes patientsInternal capsuleStriatal areasDopamine releaseHealthy subjectsAnterior limbNucleus accumbensNeuronal activity
2013
Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation
Xu X, Grijalva A, Skowronski A, van Eijk M, Serlie MJ, Ferrante AW. Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation. Cell Metabolism 2013, 18: 816-830. PMID: 24315368, PMCID: PMC3939841, DOI: 10.1016/j.cmet.2013.11.001.Peer-Reviewed Original ResearchConceptsAdipose tissue macrophagesAdipose tissueInflammatory phenotypeTissue macrophagesLipid metabolismObesity-induced inflammationSystemic immune responsesModel of obesityRecruitment of macrophagesImpairs lipid metabolismKey metabolic tissuesNoninflammatory functionsImmune cellsImmune responseClassic activationObesityMetabolic tissuesMacrophagesExcess lipidsLipid catabolismM1 stateTissueMetabolismLipid contentPhenotype