Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family
Buldyrev S, Goldberger A, Havlin S, Peng C, Stanley H, Stanley M, Simons M. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family. Biophysical Journal 1993, 65: 2673-2679. PMID: 8312501, PMCID: PMC1226007, DOI: 10.1016/s0006-3495(93)81290-6.Peer-Reviewed Original ResearchConceptsMyosin heavy chain gene familyHeavy chain gene familyIntrons-late theoryMyosin heavy chain sequencesGene evolutionMolecular evolutionGene familyNucleotide sequenceMHC genesDifferent speciesDNA walksHeavy chain sequencesFractal landscapesSequenceChain sequencesVertebratesYeastGenesEvolutionSpeciesDNALandscape analysisSimple iterative modelPolymeric sequencesFamilyRelation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy
Simons M, Leclerc G, Safian R, Isner J, Weir L, Baim D. Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy. New England Journal Of Medicine 1993, 328: 608-613. PMID: 8429852, DOI: 10.1056/nejm199303043280903.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMyosin heavy chainNonmuscle myosin heavy chainRecurrent luminal narrowingCoronary artery lesionsExercise thallium scintigraphyVascular smooth muscle cellsCoronary atherosclerotic plaquesPresence of restenosisHigh-power fieldGroup of lesionsNegative resultsAngiographic followCoronary atherectomyCoronary angioplastyThallium scintigraphyCoronary lesionsLuminal narrowingNeointimal proliferationSubsequent restenosisLate lossLuminal diameterHeavy chainHigh riskAtherectomy