2002
Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone
Ganat Y, Soni S, Chacon M, Schwartz ML, Vaccarino FM. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience 2002, 112: 977-991. PMID: 12088755, DOI: 10.1016/s0306-4522(02)00060-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCerebral CortexCerebral VentriclesEnzyme-Linked Immunosorbent AssayEpendymaFibroblast Growth Factor 1Fibroblast Growth Factor 2HypoxiaImmunohistochemistryNeurogliaRatsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorRegenerationUp-RegulationConceptsRadial glial cellsRadial gliaChronic hypoxiaGlial cellsFibroblast growth factor 1Periventricular regionBrain lipid binding proteinMajor receptorChronic hypoxic damageGlial fibrillary acidic proteinHypoxia/ischemiaSub-ventricular zoneImmature glial cellsFibrillary acidic proteinGrowth factor-1Ependymal zoneChronic hypoxemiaCerebral cortexHypoxic damageNeurotrophin familyPerinatal brainFGF receptor 1Rat pupsPostnatal weekGlial phenotypeA1 adenosine receptor activation induces ventriculomegaly and white matter loss
Turner CP, Yan H, Schwartz M, Othman T, Rivkees SA. A1 adenosine receptor activation induces ventriculomegaly and white matter loss. Neuroreport 2002, 13: 1199-1204. PMID: 12151769, DOI: 10.1097/00001756-200207020-00026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsAnimals, NewbornBody WeightCell CountCerebral CortexCerebral VentriclesDrug CombinationsDrug InteractionsGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)HippocampusMicroscopy, ElectronMyelin Basic ProteinNerve DegenerationNerve Fibers, MyelinatedNeurogliaNeuronsPresynaptic TerminalsPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P1TelencephalonTheophyllineConceptsWhite matter lossAdenosine receptor activationActivation of A1ARPostnatal day 3White matter volumeReceptor-G protein couplingMyelin basic proteinNeuronal lossAgonist treatmentNeonatal ratsN6-cyclopentyladenosineA1AR activationMatter volumeDay 3Adenosine receptorsReceptor activationBrain formationPD 4A1ARReduced expressionProtein couplingQuantitative electron microscopyVentriculomegalyBasic proteinBrain
2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABA
1998
Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain
Ment L, Schwartz M, Makuch R, Stewart W. Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat brain. Brain Research 1998, 111: 197-203. PMID: 9838111, DOI: 10.1016/s0165-3806(98)00139-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCerebral CortexCerebral VentriclesChronic DiseaseCorpus CallosumHypoxia, BrainOrgan SizeOxygenRatsConceptsChronic sublethal hypoxiaSublethal hypoxiaBronchopulmonary dysplasiaAnimal modelsExperimental rat pupsSystemic blood pressureSubcortical white matterCorpus callosum sizePostnatal day 3Third groupNeurodevelopmental handicapPreterm infantsProlonged hypoxemiaBlood pressureCerebral ventriculomegalyExperimental time pointsChronic hypoxiaControl ratsCortical volumeRat pupsCallosum sizeNewborn ratsRat brainBody weightDay 3