2016
PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells
Rehman M, Gurrapu S, Cagnoni G, Capparuccia L, Tamagnone L. PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells. PLOS ONE 2016, 11: e0164660. PMID: 27749937, PMCID: PMC5066946, DOI: 10.1371/journal.pone.0164660.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesCadherinsCell Adhesion Molecules, NeuronalCell Line, TumorCell MovementDiaminesDown-RegulationEnzyme InhibitorsHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsJagged-1 ProteinLung NeoplasmsMembrane GlycoproteinsMiceMice, Inbred NODMice, SCIDMicroscopy, FluorescencePromoter Regions, GeneticReceptors, NotchRNA InterferenceRNA, MessengerRNA, Small InterferingSignal TransductionSnail Family Transcription FactorsThiazolesTransplantation, HeterologousUp-RegulationConceptsNovel transcriptional targetProstate cancer cell migrationCell migrationCancer cell migrationTranscriptional targetsNotch signalingPlexinD1 expressionE-cadherin levelsCancer cellsProstate cancer cellsE-cadherin regulationAbsence of NotchPromoter activity reporterCancer cell invasivenessTranscription factor SlugProstate cancerProstate cancer cell invasivenessTranscriptional activationNotch receptorsActivity reporterDownstream eventsAxis downstreamNotch ligandsFunctional rescuePlexinD1
2006
Coexpression of Notch1 and NF-κB signaling pathway components in human cervical cancer progression
Ramdass B, Maliekal TT, Lakshmi S, Rehman M, Rema P, Nair P, Mukherjee G, Reddy BK, Krishna S, Pillai M. Coexpression of Notch1 and NF-κB signaling pathway components in human cervical cancer progression. Gynecologic Oncology 2006, 104: 352-361. PMID: 17098279, DOI: 10.1016/j.ygyno.2006.08.054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Squamous CellCell Line, TumorCell NucleusDisease ProgressionFemaleHumansImmunohistochemistryMiceMice, NudeNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-fosReceptor, Notch1Signal TransductionTransplantation, HeterologousTumor Suppressor Protein p53Uterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsHuman cervical cancerCervical cancerNF-kappaB p50Cancer tissuesCaSki cellsHuman cervical cancer progressionNF-kappaB.Human cervical cancer tissuesCervical cancer tissuesSquamous cell carcinomaNormal cervical tissuesCervical cancer progressionCervical tissue samplesCell line CaSkiExpression of Notch1NF-kappaB activationNF-kappaB p65Human cancer tissuesUpstream regulatorUterine cervixCell carcinomaPreinvasive lesionsCervical tissueNF-κBIkappaB-alpha