1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues
1975
Effect of lithium on water and electrolyte metabolism.
Galla J, Forrest J, Hecht B, Kashgarian M, Hayslett J. Effect of lithium on water and electrolyte metabolism. The Yale Journal Of Biology And Medicine 1975, 48: 305-14. PMID: 1202760, PMCID: PMC2595176.Peer-Reviewed Original ResearchConceptsEffects of lithiumElectrolyte transportSame nephron segmentsAction of vasopressinChronic administrationOral intakeLithium administrationIntravenous infusionPlasma levelsPotassium secretionElectrolyte metabolismMaximum urineCorticomedullary gradientUrinary acidificationNephron segmentsSustained increaseDistal portionAdministrationNatriuresisInfusionRatsVasopressinIntakeNephronSecretion
1971
Accelerated reabsorption in the proximal tubule produced by volume depletion
Weiner M, Weinman E, Kashgarian M, Hayslett J. Accelerated reabsorption in the proximal tubule produced by volume depletion. Journal Of Clinical Investigation 1971, 50: 1379-1385. PMID: 5090054, PMCID: PMC292075, DOI: 10.1172/jci106620.Peer-Reviewed Original ResearchConceptsProximal tubulesFiltration rateVolume depletionIntrinsic reabsorptive capacitySodium-free dietGlomerular filtration rateProximal fluid reabsorptionAdministration of furosemideReabsorption of fluidTechnique of micropunctureAldosterone secretionRenal responseSodium depletionDistal tubulesReabsorptive capacityBody weightChronic depletionFluid reabsorptionMarked fallExtracellular volumePlasma volumeClinical phenomenaReabsorptionTubulesPresent experiments