2003
Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo.
Khanna A, Rossman J, Caty MG, Fung H. Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo. Journal Of Surgical Research 2003, 114: 15-24. PMID: 13678693, DOI: 10.1016/s0022-4804(03)00329-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnimalsBileHemodynamicsIntestinal DiseasesIntestinal MucosaIntestinesMaleModels, AnimalNeutrophil ActivationNeutrophil InfiltrationNitric OxideNitroglycerinPermeabilityPlatelet Activating FactorRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryVasodilator AgentsConceptsIntestinal ischemia-reperfusion injuryIschemia-reperfusion injuryHealth Research FoundationBile flowMean arterial pressureAdministration of nitroglycerinIntestinal barrier functionIntestinal ischemiaMucosal injurySystemic hemodynamicsArterial pressureHypotensive effectIntestinal pathologyChildren's HospitalIntestinal IRIntestinal permeabilityRat modelSustained decreaseExperimental diseaseSystemic effectsNitroglycerinBeneficial effectsPhysiologic functionDifferent dosesBarrier function
2001
Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion
Khanna A, Rossman J, Fung H, Caty M. Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion. Journal Of Surgical Research 2001, 99: 114-119. PMID: 11421612, DOI: 10.1006/jsre.2001.6103.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHemodynamicsIntestinal MucosaIntestinesIschemiaMalePermeabilityRatsRats, Sprague-DawleyReperfusion InjurySplanchnic CirculationConceptsMean arterial pressureR injuryRat modelHeart rateAnimal modelsMesenteric ischemia/reperfusionBarrier functionReperfusion injury resultsSuperior mesenteric arteryIschemia/reperfusionNormal barrier functionArterial pressureHemodynamic effectsIntestinal damageMesenteric occlusionHemodynamic measurementsMesenteric arterySmall bowelFemoral arterySustained fallIntestinal permeabilityInjury resultsAnesthetized ratsIntestinal impairmentHistological disruption
2000
Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats
Khanna A, Rossman J, Fung H, Caty M. Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats. Biochemical And Biophysical Research Communications 2000, 269: 160-164. PMID: 10694494, DOI: 10.1006/bbrc.2000.2266.Peer-Reviewed Original ResearchConceptsNitric oxide synthase activityOxide synthase activityNOS activityReactive oxygen speciesIntestinal ischemia/reperfusion injuryIntestinal ischemia/reperfusionIschemia/reperfusion injuryInhibits neutrophil activationNOS III expressionSuperior mesenteric ischemiaIschemia/reperfusionEndogenous NO formationIntestinal tissue homogenatesWestern blot analysisIntestinal ischemiaMesenteric ischemiaNeutrophil infiltrationR injuryReperfusion injuryDeleterious stimuliNeutrophil activationSynthase activityIntestinal integrityAnimal modelsL-arginine
1997
Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung
Rossman J, Caty M, Zheng S, Karamanoukian H, Thusu K, Azizkhan R, Dandona P. Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung. Journal Of Surgical Research 1997, 73: 41-46. PMID: 9441791, DOI: 10.1006/jsre.1997.5196.Peer-Reviewed Original ResearchConceptsIntestinal mucosal injuryLung injuryMucosal injuryOxygenated perfluorocarbonLipid peroxidationDistant organ injuryIntestinal ischemia reperfusionLung lipid peroxidationPortal venous circulationPortal venous effluentOrgan injuryIschemia reperfusionMucosal protectionPortal bloodVenous effluentVenous circulationLung tissueLuminal perfusionIntraluminal oxygenOxidant injurySmall intestineInjuryOxidant generationReactive oxygen speciesPrimary effectorOxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury
O'Donnell K, Caty M, Zheng S, Rossman J, Azizkhan R. Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury. Journal Of Pediatric Surgery 1997, 32: 361-365. PMID: 9044154, DOI: 10.1016/s0022-3468(97)90211-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorocarbonsIntestinal MucosaIntestinesIschemiaMaleOxygenRatsRats, Sprague-DawleyReperfusion InjuryConceptsIschemia/reperfusion injurySuperior mesenteric arteryMucosal injuryReperfusion injuryMucosal integrityOxygenated perfluorocarbonNew treatment modalitiesR groupMesenteric insufficiencyR injuryMesenteric arteryMucosal functionTreatment modalitiesIntraluminal perfusionMucosal preservationIschemic disordersRat modelIntraluminal flowIntestinal mucosaClinical situationsInjuryIschemiaTissue sectionsReperfusionFeasible technique