2020
Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane
Wu J, Rowart P, Jouret F, Gassaway BM, Rajendran V, Rinehart J, Caplan MJ. Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane. American Journal Of Physiology - Cell Physiology 2020, 318: c486-c501. PMID: 31913699, PMCID: PMC7099514, DOI: 10.1152/ajpcell.00422.2019.Peer-Reviewed Original ResearchConceptsJunction assemblyPlasma membranePhospho-defective mutantsEpithelial junction assemblyMDCK renal epithelial cellsProtein kinase activationJunction-associated proteinsRenal epithelial cellsActive GTPEpithelial polarizationTight junction componentsZO-1 localizationAMPK activationKinase activationKey regulatorAfadinAMPKImportant regulatorJunction componentsProtein zonula occludens-1Par3Epithelial cellsTight junction protein zonula occludens-1RegulatorAssembly
1998
Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase
Li D, Cheng S, Fisone G, Caplan M, Ohtomo Y, Aperia A. Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase. American Journal Of Physiology 1998, 275: f863-f869. PMID: 9843902, DOI: 10.1152/ajprenal.1998.275.6.f863.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDopamine and cAMP-Regulated Phosphoprotein 32Dose-Response Relationship, DrugEnzyme ActivationEnzyme InhibitorsIn Vitro TechniquesKidneyMaleMarine ToxinsNerve Tissue ProteinsOkadaic AcidOxazolesPhorbol 12,13-DibutyratePhosphoprotein PhosphatasesPhosphoproteinsPhosphorylationProtein Kinase CRatsRats, Sprague-DawleySodium-Potassium-Exchanging ATPaseConceptsState of phosphorylationOkadaic acidPP-2ACalyculin AProtein kinasePP-1PP-1 activityATPase alpha subunitProtein kinase C activatorProtein phosphatasePresence of PDBuAlpha subunitATPase phosphorylationPhosphorylationC activatorProtein 1Anti-alpha antibodyATPaseATPase activityKinaseSuch regulationPDBu inhibitionPDBuPhosphataseFK-506
1995
Na+,K+-ATPase in the Choroid Plexus REGULATION BY SEROTONIN/PROTEIN KINASE C PATHWAY (∗)
Fryckstedt J, Caplan M, Aperia A, Fisone G, Snyder G, Greengard P. Na+,K+-ATPase in the Choroid Plexus REGULATION BY SEROTONIN/PROTEIN KINASE C PATHWAY (∗). Journal Of Biological Chemistry 1995, 270: 2427-2430. PMID: 7852300, DOI: 10.1074/jbc.270.6.2427.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CTwo-dimensional peptide mappingProtein kinase C pathwayKinase C pathwayProtein phosphorylationFirst messengersIntact cellsIon pumpsPeptide mappingATPaseC pathwayPhosphorylationPhorbolDemonstrated abilityMessengerComigrationActivatorRegulationPathwayActivityChoroid plexusMechanismProductionTurnover