2018
Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ
Merrick D, Mistry K, Wu J, Gresko N, Baggs JE, Hogenesch JB, Sun Z, Caplan MJ. Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ. Human Molecular Genetics 2018, 28: 16-30. PMID: 30215740, PMCID: PMC6298236, DOI: 10.1093/hmg/ddy322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBone DevelopmentCell DifferentiationE1A-Associated p300 ProteinGene Expression RegulationGenes, RegulatorHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsKidneyModels, AnimalMorpholinosOsteoblastsOsteogenesisPolycystic Kidney, Autosomal DominantTrans-ActivatorsTranscription FactorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTRPP Cation ChannelsZebrafishZebrafish ProteinsConceptsC-terminal tailCurly tail phenotypePolycystin-1Tail phenotypeTranscriptional coactivator TAZMessenger RNARunx2 transcriptional activityBone developmentTranscription factor Runx2Co-regulatory proteinsPkd1 mutant miceEssential coactivatorTranscriptional pathwaysTranscriptional activityOsteoblast differentiationKey mechanistic linkTAZPhysiological functionsPKD1 geneMechanistic linkRunx2MorpholinoPhenotypeMutant miceAutosomal dominant polycystic kidney disease
2010
Renal Cystic Proteins in the Olfactory Epithelium (OE)
Pluznick J, Rodriguez‐Gil D, Hull M, Mistry K, Gattone V, Johnson C, Weatherbee S, Greer C, Caplan M. Renal Cystic Proteins in the Olfactory Epithelium (OE). The FASEB Journal 2010, 24: 1002.17-1002.17. DOI: 10.1096/fasebj.24.1_supplement.1002.17.Peer-Reviewed Original ResearchMutant animalsPolycystin-2Olfactory epitheliumIndividual olfactory receptorsDisease-causing mutationsCilia formationΑ-tubulin stainingMurine olfactory epitheliumMature olfactory neuronsMKS3Olfactory receptorsOlfactory neuronsProteinDendritic knobsCiliaPhysiological activityMutant miceAC3 expressionVitro dataMutant ratsRT-PCRSyndrome 1Similar reductionExpressionRats