2020
Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane
Wu J, Rowart P, Jouret F, Gassaway BM, Rajendran V, Rinehart J, Caplan MJ. Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane. American Journal Of Physiology - Cell Physiology 2020, 318: c486-c501. PMID: 31913699, PMCID: PMC7099514, DOI: 10.1152/ajpcell.00422.2019.Peer-Reviewed Original ResearchConceptsJunction assemblyPlasma membranePhospho-defective mutantsEpithelial junction assemblyMDCK renal epithelial cellsProtein kinase activationJunction-associated proteinsRenal epithelial cellsActive GTPEpithelial polarizationTight junction componentsZO-1 localizationAMPK activationKinase activationKey regulatorAfadinAMPKImportant regulatorJunction componentsProtein zonula occludens-1Par3Epithelial cellsTight junction protein zonula occludens-1RegulatorAssembly
2008
The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate
Pluznick J, Zou D, Zhang X, Yan Q, Rodriguez‐Gil D, Eisner C, Wells E, Greer C, Schnermann J, Wang T, Firestein S, Caplan M. The olfactory isoform of adenylyl cyclase (AC3) in the renal macula densa serves as a key regulator of glomerular filtration rate. The FASEB Journal 2008, 22: 761.12-761.12. DOI: 10.1096/fasebj.22.1_supplement.761.12.Peer-Reviewed Original ResearchGlomerular filtration rateMacula densaTubuloglomerular feedbackFiltration rateEfferent arteriolar diametersRT-PCRPlasma renin concentrationRenal function studiesAdenylyl cyclaseWild-type littermatesOlfactory G-proteinOlfactory receptorsRenin concentrationRenin secretionArteriolar diameterOlfactory adenylyl cyclaseWestern blotMouse kidneyKidneyNon-olfactory tissuesRenal epitheliumG proteinsFunction studiesMiceKey regulator