2021
Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis
Broderick DTJ, Waite DW, Marsh RL, Camargo CA, Cardenas P, Chang AB, Cookson WOC, Cuthbertson L, Dai W, Everard ML, Gervaix A, Harris JK, Hasegawa K, Hoffman LR, Hong SJ, Josset L, Kelly MS, Kim BS, Kong Y, Li SC, Mansbach JM, Mejias A, O’Toole G, Paalanen L, Pérez-Losada M, Pettigrew MM, Pichon M, Ramilo O, Ruokolainen L, Sakwinska O, Seed PC, van der Gast CJ, Wagner BD, Yi H, Zemanick ET, Zheng Y, Pillarisetti N, Taylor MW. Bacterial Signatures of Paediatric Respiratory Disease: An Individual Participant Data Meta-Analysis. Frontiers In Microbiology 2021, 12: 711134. PMID: 35002989, PMCID: PMC8733647, DOI: 10.3389/fmicb.2021.711134.Peer-Reviewed Original ResearchPediatric respiratory diseasesIndividual participant dataRespiratory diseaseLower airway samplesIndividual Participant Data Meta-AnalysisChronic respiratory conditionsData Meta-AnalysisPositive predictive valueCross-sectional analysisAirway microbiotaAirway samplesRespiratory conditionsCase subjectsRespiratory microbiotaAnatomical sitesPredictive valueSingle diseaseMeta-AnalysisClinical diagnosisMicrobiota differencesDiseaseDiagnostic groupingsParticipant dataMicrobiota associationsMultiple diseases
2016
Association of sputum microbiota profiles with severity of community-acquired pneumonia in children
Pettigrew MM, Gent JF, Kong Y, Wade M, Gansebom S, Bramley AM, Jain S, Arnold SL, McCullers JA. Association of sputum microbiota profiles with severity of community-acquired pneumonia in children. BMC Infectious Diseases 2016, 16: 317. PMID: 27391033, PMCID: PMC4939047, DOI: 10.1186/s12879-016-1670-4.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCAP severityMicrobiota profilesClinical courseRespiratory microbiotaPediatric community-acquired pneumoniaIntensive care unit admissionNasopharyngeal/oropharyngeal samplesCare unit admissionOdds of lengthInduced sputum samplesRespiratory tract microbiotaOP samplesRibosomal RNA sequencingUnit admissionDecreased oddsSputum samplesChildren 6Oropharyngeal samplesMicrobiota influenceChildren 5Logistic regressionSputumSeverityPneumonia