2023
Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice
Tran J, Muench M, Gaillard B, Darst O, Tomayko M, Jackman R. Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice. Frontiers In Immunology 2023, 14: 1281130. PMID: 38146372, PMCID: PMC10749330, DOI: 10.3389/fimmu.2023.1281130.Peer-Reviewed Original ResearchConceptsB cell responsesPlatelet transfusionsMajor histocompatibility complexCell responsesPrior exposurePlatelet alloimmunizationMemory B cell responsesPlatelet transfusion recipientsSubsequent platelet transfusionsAllogeneic platelet transfusionsNegative bacterial infectionsPolyinosinic-polycytidylic acidGerminal center formationPrior inflammationAlloantibody responsesAlloimmune responsePlatelet refractorinessFuture transplantTransfusion recipientsMHC tetramersAdverse reactionsInflammatory environmentAntigen experiencePlatelet antigensTransfusionEnhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice
Jackman R, Darst O, Gaillard B, Tran J, Tomayko M, Muench M. Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice. Frontiers In Immunology 2023, 14: 1281123. PMID: 38090570, PMCID: PMC10711281, DOI: 10.3389/fimmu.2023.1281123.Peer-Reviewed Original ResearchConceptsAblative chemotherapyAlloantibody responsesPlatelet transfusionsB cellsPotent immunological effectsT cell responsesImpact of chemotherapyTransitional B cellsAllogeneic platelet transfusionsRisk of alloimmunizationNon-specific activationSubsequent transfusionsAllogeneic plateletsLymphocyte depletionBlood transfusionImmune dysregulationPlatelet recipientsSerum levelsPatient populationImmunological effectsImmunological environmentTransfusionRejection of transplantsChemotherapyHealthy people
2019
B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors
Damsky W, Jilaveanu L, Turner N, Perry C, Zito C, Tomayko M, Leventhal J, Herold K, Meffre E, Bosenberg M, Kluger HM. B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors. Journal For ImmunoTherapy Of Cancer 2019, 7: 153. PMID: 31200747, PMCID: PMC6567557, DOI: 10.1186/s40425-019-0613-1.Peer-Reviewed Original ResearchConceptsPD-1 inhibitorsB cell contentB-cell depletionAnti-tumor activityB cellsMuMT miceCell depletionAnti-PD-1 inhibitorsAnti-PD-1 responseB-cell depleting drugsTumor-infiltrating B cellsImpaired B-cell functionT cell-dependent tumor rejectionPD-1 inhibitionMC38 colon cancerB cell functionAnti-tumor effectsB-cell malignanciesMurine cancer modelsCell contentOverall survivalTumor rejectionCD20 antibodyAutoimmune disordersTumor shrinkageWhat B cell memories are made of
Tomayko MM, Allman D. What B cell memories are made of. Current Opinion In Immunology 2019, 57: 58-64. PMID: 30861463, DOI: 10.1016/j.coi.2019.01.003.Peer-Reviewed Original ResearchConceptsMemory B cellsB cell memoryB cellsPlasma cellsCell memoryAntigen-specific B cell receptorProtective serum antibodiesB cell receptorHumoral immunityIgG antibodiesSerum antibodiesSecondary exposureCell receptorUltimate outcomeAntigenAntibodiesMolecular eventsSame cellular pathwaysCellsCellular pathwaysIgMPathwayImmunityReceptors
2014
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
Zuccarino-Catania GV, Sadanand S, Weisel FJ, Tomayko MM, Meng H, Kleinstein SH, Good-Jacobson KL, Shlomchik MJ. CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nature Immunology 2014, 15: 631-637. PMID: 24880458, PMCID: PMC4105703, DOI: 10.1038/ni.2914.Peer-Reviewed Original ResearchCD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
Conter LJ, Song E, Shlomchik MJ, Tomayko MM. CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence. PLOS ONE 2014, 9: e92009. PMID: 24664100, PMCID: PMC3963874, DOI: 10.1371/journal.pone.0092009.Peer-Reviewed Original ResearchConceptsMurine memory B cellsPlasma cellsCD73 expressionBone marrow (BM) PCsB cellsCell responsesDependent B cell responsesBone marrow plasma cellsFollicular helper cellsT cell responsesB cell responsesMemory B cellsMarrow plasma cellsWild-type miceGerminal center B cellsCD73 knockout miceEarly secondary responseHelper cellsHumoral immunityT lymphocytesPC compartmentAdenosine signalingType miceGerminal centersKnockout mice
2010
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets
Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets. The Journal Of Immunology 2010, 185: 7146-7150. PMID: 21078902, PMCID: PMC3133669, DOI: 10.4049/jimmunol.1002163.Peer-Reviewed Original ResearchPD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunology 2010, 11: 535-542. PMID: 20453843, PMCID: PMC2874069, DOI: 10.1038/ni.1877.Peer-Reviewed Original Research
2008
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponse
1998
B cell maturation and selection at the marrow-periphery interface
Cancro M, Allman D, Hayes C, Lentz V, Fields R, Sah A, Tomayko M. B cell maturation and selection at the marrow-periphery interface. Immunologic Research 1998, 17: 3-11. PMID: 9479562, DOI: 10.1007/bf02786425.Peer-Reviewed Original ResearchConceptsB cell differentiationCell differentiationB cell longevityNormal B cell differentiationRegulatory genesSelective eventsNatural mutationsExpression changesB cell maturationCell longevityCell maturationLate maturationDifferentiationMaturationBone marrowPoolB cellsGenesDeletionMutationsRecruitmentLongevityCellsCritical periodEvents
1996
Human neuroblastoma cell lines regain catecholamine fluorescence when xenografted into athymic (nude) mice
Tomayko M, Triche T, Reynolds C. Human neuroblastoma cell lines regain catecholamine fluorescence when xenografted into athymic (nude) mice. International Journal Of Developmental Neuroscience 1996, 14: 771-777. PMID: 8960984, DOI: 10.1016/s0736-5748(96)00050-0.Peer-Reviewed Original ResearchConceptsNeuroblastoma cell linesPrimitive neuroectodermal tumorHuman neuroblastoma cell lineCatecholamine fluorescenceDense core granulesCatecholamine productionXenograft tumorsAthymic miceCell linesGlyoxylic acid-induced catecholamine fluorescenceHistochemical evidenceCore granulesNude mice tumor tissuesUseful tumor markerHuman neuroblastoma cellsMouse tumor tissuesNeuroblastoma patientsNeuroectodermal tumorUrinary catecholaminesTumor markersCatecholamine synthesisCorresponding tumorsHuman neuronsTumor tissueTumors
1989
Determination of subcutaneous tumor size in athymic (nude) mice
Tomayko M, Reynolds C. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemotherapy And Pharmacology 1989, 24: 148-154. PMID: 2544306, DOI: 10.1007/bf00300234.Peer-Reviewed Original Research