2023
Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice
Jackman R, Darst O, Gaillard B, Tran J, Tomayko M, Muench M. Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice. Frontiers In Immunology 2023, 14: 1281123. PMID: 38090570, PMCID: PMC10711281, DOI: 10.3389/fimmu.2023.1281123.Peer-Reviewed Original ResearchConceptsAblative chemotherapyAlloantibody responsesPlatelet transfusionsB cellsPotent immunological effectsT cell responsesImpact of chemotherapyTransitional B cellsAllogeneic platelet transfusionsRisk of alloimmunizationNon-specific activationSubsequent transfusionsAllogeneic plateletsLymphocyte depletionBlood transfusionImmune dysregulationPlatelet recipientsSerum levelsPatient populationImmunological effectsImmunological environmentTransfusionRejection of transplantsChemotherapyHealthy peopleMicrofluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection
Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection. Small Methods 2023, 7: e2300594. PMID: 37312418, PMCID: PMC10592458, DOI: 10.1002/smtd.202300594.Peer-Reviewed Original ResearchConceptsB cell depletion therapyAcute COVID infectionAnti-spike IgGHigh-risk patientsCoronavirus disease-19COVID-19 pathologyDepletion therapyVaccine protectionAntibody responseCOVID infectionHematologic malignanciesImmune protectionDisease-19Healthy donorsMultiple time pointsSerology assaysBlood samplesSoluble markersB cellsImmunization strategiesPatientsFunctional deficiencySerological analysisTime pointsClonotype diversity
2021
30 Rituximab
Gehlhausen J, Heffernan M, Tomayko M. 30 Rituximab. 2021, 330-338.e3. DOI: 10.1016/b978-0-323-61211-1.00030-9.ChaptersMucous membrane pemphigoidEpidermolysis bullosa acquisitaMechanism of actionCutaneous lupusHost diseaseBullous pemphigoidPemphigus vulgarisPemphigus foliaceusRituximabB cellsUS FoodDrug AdministrationDermatologic usesMonoclonal antibodiesPemphigoidTreatmentCD20AcquisitaLupusFoliaceusGraftDiseaseAdministrationAntibodiesPharmacology
2019
B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors
Damsky W, Jilaveanu L, Turner N, Perry C, Zito C, Tomayko M, Leventhal J, Herold K, Meffre E, Bosenberg M, Kluger HM. B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors. Journal For ImmunoTherapy Of Cancer 2019, 7: 153. PMID: 31200747, PMCID: PMC6567557, DOI: 10.1186/s40425-019-0613-1.Peer-Reviewed Original ResearchConceptsPD-1 inhibitorsB cell contentB-cell depletionAnti-tumor activityB cellsMuMT miceCell depletionAnti-PD-1 inhibitorsAnti-PD-1 responseB-cell depleting drugsTumor-infiltrating B cellsImpaired B-cell functionT cell-dependent tumor rejectionPD-1 inhibitionMC38 colon cancerB cell functionAnti-tumor effectsB-cell malignanciesMurine cancer modelsCell contentOverall survivalTumor rejectionCD20 antibodyAutoimmune disordersTumor shrinkageWhat B cell memories are made of
Tomayko MM, Allman D. What B cell memories are made of. Current Opinion In Immunology 2019, 57: 58-64. PMID: 30861463, DOI: 10.1016/j.coi.2019.01.003.Peer-Reviewed Original ResearchConceptsMemory B cellsB cell memoryB cellsPlasma cellsCell memoryAntigen-specific B cell receptorProtective serum antibodiesB cell receptorHumoral immunityIgG antibodiesSerum antibodiesSecondary exposureCell receptorUltimate outcomeAntigenAntibodiesMolecular eventsSame cellular pathwaysCellsCellular pathwaysIgMPathwayImmunityReceptors
2017
B Cell Biology
Sadanand S, Tomayko M. B Cell Biology. 2017, 97-119. DOI: 10.1007/978-3-319-29785-9_7.ChaptersB cell biologyCell biologyB cellsImmune responseEffector functionsB cell-T cell interactionsCell-T cell interactionsB cell developmentCurrent therapeutic mechanismsRegulatory B cellsB-cell depletionB cell responsesAdaptive immune responsesMemory B cellsGerminal center responseEstablishment of toleranceCell developmentCentral playerProtective immunityCell depletionDurable immunityAntigenic targetsAntibody isotypesPlasma cellsTherapeutic mechanism
2014
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
Zuccarino-Catania GV, Sadanand S, Weisel FJ, Tomayko MM, Meng H, Kleinstein SH, Good-Jacobson KL, Shlomchik MJ. CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nature Immunology 2014, 15: 631-637. PMID: 24880458, PMCID: PMC4105703, DOI: 10.1038/ni.2914.Peer-Reviewed Original ResearchCD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
Conter LJ, Song E, Shlomchik MJ, Tomayko MM. CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence. PLOS ONE 2014, 9: e92009. PMID: 24664100, PMCID: PMC3963874, DOI: 10.1371/journal.pone.0092009.Peer-Reviewed Original ResearchConceptsMurine memory B cellsPlasma cellsCD73 expressionBone marrow (BM) PCsB cellsCell responsesDependent B cell responsesBone marrow plasma cellsFollicular helper cellsT cell responsesB cell responsesMemory B cellsMarrow plasma cellsWild-type miceGerminal center B cellsCD73 knockout miceEarly secondary responseHelper cellsHumoral immunityT lymphocytesPC compartmentAdenosine signalingType miceGerminal centersKnockout mice
2010
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets
Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets. The Journal Of Immunology 2010, 185: 7146-7150. PMID: 21078902, PMCID: PMC3133669, DOI: 10.4049/jimmunol.1002163.Peer-Reviewed Original Research
2008
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponseBLyS Neutralization Ablates Primary But Not Memory B Cell Pools
Crowley J, Scholz J, Tomayko M, Steinel N, O'Neill P, Miller J, Cho Y, Long V, Ward C, Migone T, Shlomchik M, Cancro M. BLyS Neutralization Ablates Primary But Not Memory B Cell Pools. The FASEB Journal 2008, 22: 366-366. DOI: 10.1096/fasebj.22.2_supplement.366.Peer-Reviewed Original ResearchMemory B cellsB cell poolB cellsMemory B cell poolPeripheral B cell poolRole of BLySSerum BLyS levelsCell poolMarginal zone B cellsTransitional B cellsB cell subsetsMZ B cellsAnti-BlyS antibodyAntigen rechallengeUntreated miceAntibody levelsBLyS levelsAntigen responseCell subsetsIndependent antigensPrimary B cellsAttenuated responseMiceHomeostatic nichesBLyS
1998
B cell maturation and selection at the marrow-periphery interface
Cancro M, Allman D, Hayes C, Lentz V, Fields R, Sah A, Tomayko M. B cell maturation and selection at the marrow-periphery interface. Immunologic Research 1998, 17: 3-11. PMID: 9479562, DOI: 10.1007/bf02786425.Peer-Reviewed Original ResearchConceptsB cell differentiationCell differentiationB cell longevityNormal B cell differentiationRegulatory genesSelective eventsNatural mutationsExpression changesB cell maturationCell longevityCell maturationLate maturationDifferentiationMaturationBone marrowPoolB cellsGenesDeletionMutationsRecruitmentLongevityCellsCritical periodEvents