2022
Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly
Tong D, Soley N, Kolasangiani R, Schwartz M, Bidone T. Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly. Biophysical Journal 2022, 122: 533-543. PMID: 36566352, PMCID: PMC9941721, DOI: 10.1016/j.bpj.2022.12.032.Peer-Reviewed Original ResearchBlood PlateletsLigandsMolecular Dynamics SimulationPlatelet Glycoprotein GPIIb-IIIa ComplexProtein ConformationProtein Structure, Secondary
2018
Talin as a mechanosensitive signaling hub
Goult BT, Yan J, Schwartz MA. Talin as a mechanosensitive signaling hub. Journal Of Cell Biology 2018, 217: 3776-3784. PMID: 30254032, PMCID: PMC6219721, DOI: 10.1083/jcb.201808061.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsExtracellular MatrixHumansIntegrinsMechanotransduction, CellularProtein DomainsProtein Structure, SecondaryTalinConceptsSignaling hubsExtracellular matrixRod domainTalin rod domainIntegrin β subunitsDifferent protein interactionsLong rod domainSwitch-like behaviorActin cytoskeletonCytoplasmic domainCytoplasmic proteinsProtein interactionsHelical bundleGlobular head domainTalin functionTransmembrane receptorsHelix bundleΒ-subunitHead domainIntegrin familyTalinCell adhesionIndividual domainsRecent evidenceDomain