2021
MEKK3–TGFβ crosstalk regulates inward arterial remodeling
Deng H, Xu Y, Hu X, Zhuang ZW, Chang Y, Wang Y, Ntokou A, Schwartz MA, Su B, Simons M. MEKK3–TGFβ crosstalk regulates inward arterial remodeling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2112625118. PMID: 34911761, PMCID: PMC8713777, DOI: 10.1073/pnas.2112625118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene DeletionGene Expression RegulationGenotypeHindlimbHuman Umbilical Vein Endothelial CellsHumansHypertension, PulmonaryIschemiaMAP Kinase Kinase Kinase 1MAP Kinase Kinase Kinase 3MiceReceptors, Transforming Growth Factor betaSelective Estrogen Receptor ModulatorsSignal TransductionTamoxifenTransforming Growth Factor betaVascular RemodelingConceptsArterial remodelingSuch common diseasesEndothelial-specific deletionActivation of TGFβArtery diseaseHyperlipidemic miceSpontaneous hypertensionInward remodelingAccelerated progressionArterial diameterVascular remodelingPathogenic importanceAdult miceKnockout miceVascular circuitPathologic conditionsCommon diseaseMAPK ERK1/2MiceRemodelingHypertensionAtherosclerosisControl of proliferationDiseaseProgression
2013
Flow-dependent cellular mechanotransduction in atherosclerosis
Conway DE, Schwartz MA. Flow-dependent cellular mechanotransduction in atherosclerosis. Journal Of Cell Science 2013, 126: 5101-5109. PMID: 24190880, PMCID: PMC3828588, DOI: 10.1242/jcs.138313.Peer-Reviewed Original Research
2012
p21-Activated kinase 4 promotes prostate cancer progression through CREB
Park M, Lee H, Lee C, You S, Kim D, Park B, Kang M, Heo W, Shin E, Schwartz M, Kim E. p21-Activated kinase 4 promotes prostate cancer progression through CREB. Oncogene 2012, 32: 2475-2482. PMID: 22710715, DOI: 10.1038/onc.2012.255.Peer-Reviewed Original ResearchConceptsP21-activated kinase 4Prostate cancer progressionProstate cancerCancer progressionLNCaP-FGC cellsPromising therapeutic targetKinase 4Prostate cancer cellsDU145 prostate cancer cellsSpecific protein kinase A (PKA) inhibitorProtein kinase A (PKA) inhibitorElevation of cAMPNeuroendocrine differentiationNude miceTherapeutic targetActive PAK4Downstream effector pathwaysTumor progressionDecreased expressionTumor formationCancerCancer cellsPC-3ProgressionEffector pathways
2008
The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis
Hahn C, Schwartz MA. The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2008, 28: 2101-2107. PMID: 18787190, PMCID: PMC2737679, DOI: 10.1161/atvbaha.108.165951.Peer-Reviewed Original ResearchConceptsDisease progressionChronic inflammatory diseaseSystemic risk factorsInflammatory pathwaysInflammatory diseasesRisk factorsRegions of arteriesPlaque formationAtherosclerosisProgressionCellular adaptationPotential mechanosensorsAdaptive responseCellular responsesGene expressionHyperlipidemiaSubsequent changesSmokingDiabetesArteryPathwayDiseaseVasculatureResponse
1999
Interactions between mitogenic stimuli, or, a thousand and one connections
Schwartz M, Baron V. Interactions between mitogenic stimuli, or, a thousand and one connections. Current Opinion In Cell Biology 1999, 11: 197-202. PMID: 10209147, DOI: 10.1016/s0955-0674(99)80026-x.Peer-Reviewed Original Research