2008
Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies
JAMES J, MAMULA M, HARLEY J. Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies. Clinical & Experimental Immunology 2008, 98: 419-426. PMID: 7527740, PMCID: PMC1534503, DOI: 10.1111/j.1365-2249.1994.tb05507.x.Peer-Reviewed Original ResearchConceptsMRL-lpr/lpr miceLpr/lpr miceAutoimmune serologySLE patientsLpr micePatient seraEpitope 5Systemic lupus erythematosus (SLE) patient seraEpstein-Barr nuclear antigen 1Lupus patients' seraNuclear antigen 1Precipitin-positive seraHuman lupus autoantibodiesNormal human serumMajor antigenic regionSm DPositive patientsAutoimmune responseSm autoantigenLupus autoantibodiesNormal controlsPatientsEpitope 4Mouse serumAntigen 1
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1993
Rules for Peptide Presentation by MHC Class II Molecules
Janeway C, Mamula M, Rudensky A. Rules for Peptide Presentation by MHC Class II Molecules. International Reviews Of Immunology 1993, 10: 301-311. PMID: 8294843, DOI: 10.3109/08830189309061705.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexForeign MHC moleculesMHC class II moleculesClass II moleculesOrgan transplantationT lymphocytesTissue graftMHC moleculesPeptide presentationRejection processHistocompatibility complexGraftTissue cellsUnrelated individualsRapid destructionIndividualsCellsTransplantationLymphocytesMore loci
1992
Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.
Mamula M, Lin R, Janeway C, Hardin J. Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. The Journal Of Immunology 1992, 149: 789-95. PMID: 1321851, DOI: 10.4049/jimmunol.149.3.789.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAutoantigensAutoimmunityB-LymphocytesCross ReactionsCytochrome c GroupGene Rearrangement, beta-Chain T-Cell Antigen ReceptorHumansImmune ToleranceLymphocyte ActivationMiceMice, Inbred StrainsRatsReceptors, Antigen, T-Cell, alpha-betaSequence AlignmentSpecies SpecificityT-LymphocytesConceptsT cell responsesT cell toleranceB cellsCell responsesCell toleranceSelf-AgAutoimmune T cell responsesAutoreactive T cell responsesAutoreactive T cell clonesTCR genesAutoimmune B cellsCellular immune responsesImmune B cellsAutoreactive B cellsT cell clonesT cell epitopesAmino acids 54Autoimmune diseasesT cellsImmune responseCell epitopesForeign pathogensModel autoantigenImmunizationCell clones