2001
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Liu J, Anderson B, Robert M, McNiff J, Emerson S, Shlomchik W, Shlomchik M. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 2001, 98: 3367-3375. PMID: 11719376, DOI: 10.1182/blood.v98.12.3367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCytokinesDisease Models, AnimalFlow CytometryGanciclovirGraft vs Host DiseaseGraft vs Leukemia EffectHematopoiesisHematopoietic Stem CellsInterleukin-2Interleukin-4Lymphocyte SubsetsMaleMiceMice, TransgenicPromoter Regions, GeneticSimplexvirusSpleenThymidine KinaseThymus GlandT-LymphocytesWeight GainConceptsDonor T cellsT cellsT2 cellsGVHD reactionsHost diseaseInterleukin-2Herpes simplex virus thymidine kinase gene transductionAllogeneic stem cell transplantationCytokine-producing T cellsPrevention of GVHDStem cell transplantationReversal of diseaseT cell deletionLater time pointsAcute graftCytokine polarizationOngoing GVHDClinical GVHDAntibody infusionPeak diseaseClinical effectsCell transplantationIL-4 promoterGVHDDeficient mice
1994
THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION
McDIARMID S, FARMER D, KUNIYOSHI J, ROBERT M, KHADAVI A, SHAKED A, BUSUTTIL R. THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION. Transplantation 1994, 58: 690-697. DOI: 10.1097/00007890-199409000-00009.Peer-Reviewed Original ResearchSmall intestine transplantationReverse transcriptase-PCRInterleukin-2POD 14POD 3POD 7Cytokine expressionIL-6Tumor necrosis factor αIntragraft cytokine expressionSeverity of rejectionEvidence of rejectionIL-2 receptorNecrosis factor αSemiquantitative reverse transcriptase-PCRRat small intestineExpression of mRNAIntestine transplantationLewis recipientsHistologic rejectionAllograft groupIntragraft expressionMild rejectionPOD 5Histologic evidenceTHE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION
McDIARMID S, FARMER D, KUNIYOSHI J, ROBERT M, KHADAVI A, SHAKED A, BUSUTTIL R. THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION. Transplantation 1994, 58: 690-697. PMID: 7940688, DOI: 10.1097/00007890-199409270-00009.Peer-Reviewed Original ResearchConceptsSmall intestine transplantationInterleukin-6Reverse transcriptase-PCRTNF-alphaInterleukin-2IFN-gammaPOD 14POD 3POD 7Cytokine expressionTumor necrosis factor alphaIntragraft cytokine expressionSeverity of rejectionEvidence of rejectionIL-2 receptorNecrosis factor alphaSemiquantitative reverse transcriptase-PCRRat small intestineExpression of mRNAIntestine transplantationGraft lossLewis recipientsHistologic rejectionIntragraft expressionMild rejection