2013
Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery
Carleton HA, Lara-Tejero M, Liu X, Galán JE. Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Nature Communications 2013, 4: 1590. PMID: 23481398, PMCID: PMC3693737, DOI: 10.1038/ncomms2594.Peer-Reviewed Original ResearchConceptsBacterial minicellsPresentation pathwayVaccine developmentClass IAntigen-specific CD8Antigen delivery platformSalmonella typhimurium type III secretion systemDelivery platformType III secretion systemCellular immunotherapyT cellsAntigen deliveryImmune responseHeterologous antigensProtein antigensSecretion systemCertain populationsAntigenNanoparticlesDeliveryNanomachinesCD8ImmunotherapyPathwayNovel approach
2006
Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse
Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA. Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse. Immunity 2006, 25: 941-952. PMID: 17137799, DOI: 10.1016/j.immuni.2006.09.013.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocytesInterleukin-10T cellsColonic lamina propria lymphocytesIL-10 protein expressionIL-10-producing T cellsSmall intestinal intraepithelial lymphocytesLamina propria lymphocytesRegulatory T cellsIntestinal intraepithelial lymphocytesAnti-CD3 treatmentIL-10 geneRegulation of inflammationRegulatory cells 1T cell receptor stimulationCell receptor stimulationIntestinal lymphocytesIL-10Receptor stimulationSmall intestineKnockin miceLymphocytesCells 1Protein expressionStrong expression
2004
Rapid Development of T Cell Memory
Wong P, Lara-Tejero M, Ploss A, Leiner I, Pamer EG. Rapid Development of T Cell Memory. The Journal Of Immunology 2004, 172: 7239-7245. PMID: 15187098, DOI: 10.4049/jimmunol.172.12.7239.Peer-Reviewed Original ResearchConceptsMemory T cellsT cell populationsPrimary immune responseT cellsPrimary immunizationImmune responseMemory CD8 T cell responsesAg-specific CD8 T cellsCD8 T cell responsesEarly memory T cellsCD8 T cell populationsEffector T cell populationsPrime-boost immunizationPrime-boost vaccinationCD8 T cellsPrime-boost strategyT cell memoryT cell responsesCell populationsEarly time pointsProtective immunityAg doseCell memoryCell responsesImmunization