Featured Publications
American Heart Association Cardiogenic Shock Registry: Design and Implementation
Morrow D, Jessup M, Abraham W, Acker M, Aringo A, Batchelor W, Chikwe J, Costello S, Drakos S, Farmer S, Gelijns A, Gillette N, Hochman J, Isler M, Kapur N, Kilic A, Kormos R, Lewis E, Lindenfeld J, Lombardi P, Mancini D, Rao S, Rutan C, Samsky M, Krucoff M. American Heart Association Cardiogenic Shock Registry: Design and Implementation. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010637. PMID: 38887950, DOI: 10.1161/circoutcomes.123.010637.Peer-Reviewed Original ResearchImprove quality of careQuality of careProcesses of careQuality improvement registryPragmatic randomized trialMonitoring of outcomesShock registryElectronic case record formPatient-level dataImplementation researchHealth systemImprovement registryCase record formClinical specialtiesParticipating hospitalsParticipating sitesIn-hospital survivalImprove qualityAssociational volunteeringRecord formCardiogenic shockRegistryPrecision medicine platformData structureComplications of heart diseaseSCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021.
Naidu S, Baran D, Jentzer J, Hollenberg S, van Diepen S, Basir M, Grines C, Diercks D, Hall S, Kapur N, Kent W, Rao S, Samsky M, Thiele H, Truesdell A, Henry T. SCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021. Journal Of The American College Of Cardiology 2022, 79: 933-946. PMID: 35115207, DOI: 10.1016/j.jacc.2022.01.018.Peer-Reviewed Original ResearchCardiogenic Shock After Acute Myocardial Infarction
Samsky M, Morrow D, Proudfoot A, Hochman J, Thiele H, Rao S. Cardiogenic Shock After Acute Myocardial Infarction. JAMA 2021, 326: 1840-1850. PMID: 34751704, PMCID: PMC9661446, DOI: 10.1001/jama.2021.18323.Peer-Reviewed Original ResearchCardiac safety research consortium “shock II” think tank report: Advancing practical approaches to generating evidence for the treatment of cardiogenic shock
Samsky M, Krucoff M, Morrow D, Abraham W, Aguel F, Althouse A, Chen E, Cigarroa J, DeVore A, Farb A, Gilchrist I, Henry T, Hochman J, Kapur N, Morrow V, Ohman E, O'Neill W, Piña I, Proudfoot A, Sapirstein J, Seltzer J, Senatore F, Shinnar M, Simonton C, Tehrani B, Thiele H, Truesdell A, Waksman R, Rao S. Cardiac safety research consortium “shock II” think tank report: Advancing practical approaches to generating evidence for the treatment of cardiogenic shock. American Heart Journal 2020, 230: 93-97. PMID: 33011148, PMCID: PMC7704747, DOI: 10.1016/j.ahj.2020.09.015.Peer-Reviewed Original ResearchTrends in Readmissions and Length of Stay for Patients Hospitalized With Heart Failure in Canada and the United States
Samsky M, Ambrosy A, Youngson E, Liang L, Kaul P, Hernandez A, Peterson E, McAlister F. Trends in Readmissions and Length of Stay for Patients Hospitalized With Heart Failure in Canada and the United States. JAMA Cardiology 2019, 4: 444-453. PMID: 30969316, PMCID: PMC6537806, DOI: 10.1001/jamacardio.2019.0766.Peer-Reviewed Original Research
2024
The Impact of Socioeconomic Status and Diagnostic Timeline on Clinical Outcomes in ATTR Cardiomyopathy
Chi K, Gallegos-Kattán C, Sikand N, Samsky M, Nanna M. The Impact of Socioeconomic Status and Diagnostic Timeline on Clinical Outcomes in ATTR Cardiomyopathy. Journal Of The American College Of Cardiology 2024, 84: e289-e290. PMID: 39505422, DOI: 10.1016/j.jacc.2024.07.050.Peer-Reviewed Original ResearchBiomarkers of cardiohepatic syndrome in the cardiac intensive care unit
Butt A, Padkins M, Crespo-Diaz R, Hillerson D, Katz J, Kamath P, Miller E, Rosenbaum A, Samsky M, Kashani K, Jentzer J. Biomarkers of cardiohepatic syndrome in the cardiac intensive care unit. European Heart Journal 2024, 45: ehae666.1742. DOI: 10.1093/eurheartj/ehae666.1742.Peer-Reviewed Original ResearchCardiac intensive care unitLiver function test abnormalitiesLiver function testsIn-hospital mortalityCardiac intensive care unit patientsCTCAE grade 1LFT valuesIntensive care unitOdds ratioCICU patientsConfidence intervalsCardiohepatic syndromeMeeting criteriaRisk of in-hospital mortalityAdmission liver function testsRisk prediction toolsCardiac intensive care unit admissionHigher risk of in-hospital mortalityCare unitAssociated with higher in-hospital mortalityGrade 1Associated with in-hospital mortalityElevated LFT valuesHigher in-hospital mortalityCommon Terminology CriteriaMaternal Bereavement and Heart Failure Risk of the Offspring
Goldstein S, Pastor T, Samsky M. Maternal Bereavement and Heart Failure Risk of the Offspring. JACC Heart Failure 2024, 12: 1363-1364. PMID: 39111951, DOI: 10.1016/j.jchf.2024.06.002.Peer-Reviewed Original ResearchAssociation Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
Jamil Y, Park D, Rao S, Ahmad Y, Sikand N, Bosworth H, Coles T, Damluji A, Nanna M, Samsky M. Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Advances 2024, 3: 100949. PMID: 38938859, PMCID: PMC11198471, DOI: 10.1016/j.jacadv.2024.100949.Peer-Reviewed Original ResearchAcute myocardial infarctionAMI-CSIn-hospital outcomesDo-not-resuscitate statusPatients admitted with acute myocardial infarctionOdds of in-hospital mortalitySkilled nursing facilityPrevalence of frailtyProportion of hospitalsAssociated with in-hospital outcomesIn-hospital adverse eventsCompare in-hospital outcomesRisk score cut-offNational Inpatient SampleNursing facilitiesIn-hospital mortalityScore cut-offAssociated with adverse outcomesInpatient SampleFrailtyCardiogenic shockIn-hospital morbidityMyocardial infarction complicationsNonfrail groupOddsComparative analysis of treatment options for chronic heart failure and depression: a systematic review and Bayesian network meta-analysis
Soleimani H, Nasrollahizadeh A, Hajiqasemi M, Ebrahimzade M, Taheri H, Ebrahimi P, Ashraf H, Samsky M, Hosseini K. Comparative analysis of treatment options for chronic heart failure and depression: a systematic review and Bayesian network meta-analysis. Heart Failure Reviews 2024, 29: 841-852. PMID: 38613598, DOI: 10.1007/s10741-024-10403-z.Peer-Reviewed Original ResearchCognitive behavioral therapyDepression scoresMeasures of depressionTreatment of depressionRandomized controlled trialsHeart failureStandardized mean differenceBehavioral therapyTreatment optionsAnalysis of treatment optionsDepressionEfficacious treatmentMeta-analysisBayesian network meta-analysisChronic heart failureHeart failure patientsNetwork meta-analysisFailure patientsPrimary outcomeWeb of Science databasesControlled trialsMean differencePatientsScoresSystematic reviewFrailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction
Park D, Jamil Y, Ahmad Y, Coles T, Bosworth H, Sikand N, Davila C, Babapour G, Damluji A, Rao S, Nanna M, Samsky M. Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction. Journal Of Clinical Medicine 2024, 13: 2078. PMID: 38610842, PMCID: PMC11012362, DOI: 10.3390/jcm13072078.Peer-Reviewed Original ResearchDo-not-resuscitate statusOdds of in-hospital mortalitySkilled nursing facilityIn-hospital adverse eventsRelationship of frailtyCompare in-hospital outcomesNon-frail groupRisk score cut-offNational Inpatient SampleAssociated with increased rates of morbidityNursing facilitiesMyocardial infarctionAssociated with increased ratesFrail adultsIn-hospital mortalityIn-hospital outcomesAcute myocardial infarctionFrail groupScore cut-offFrailtyInpatient SampleCardiogenic shockRisk factorsCardiovascular diseaseHospitalAssociation of cardiovascular diseases with cognitive performance in older adults
Park D, Jamil Y, Babapour G, Kim J, Campbell G, Akman Z, Kochar A, Sen S, Samsky M, Sikand N, Frampton J, Damluji A, Nanna M. Association of cardiovascular diseases with cognitive performance in older adults. American Heart Journal 2024, 273: 10-20. PMID: 38575050, PMCID: PMC11162917, DOI: 10.1016/j.ahj.2024.03.016.Peer-Reviewed Original ResearchAnimal Fluency TestOlder adultsCERAD-DRDSST scoresCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCongestive heart failureFree of cardiovascular diseaseFluency testCardiovascular disease subtypesNutrition Examination SurveyAssociation of cardiovascular diseaseAnimal Fluency test scoreCognitive performanceLower cognitive performanceCoronary heart diseaseHeart failureCVD subtypesExamination SurveyAssess cognitive performanceAdultsCognitive functionHeart diseaseScoresThe management of heart failure cardiogenic shock: an international RAND appropriateness panel
Williams S, Kalakoutas A, Olusanya S, Schrage B, Tavazzi G, Carnicelli A, Montero S, Vandenbriele C, Luk A, Lim H, Bhagra S, Ott S, Farrero M, Samsky M, Kennedy J, Sen S, Agrawal R, Rampersad P, Coniglio A, Pappalardo F, Barnett C, Proudfoot A. The management of heart failure cardiogenic shock: an international RAND appropriateness panel. Critical Care 2024, 28: 105. PMID: 38566212, PMCID: PMC10988801, DOI: 10.1186/s13054-024-04884-5.Peer-Reviewed Original ResearchConceptsTemporary mechanical circulatory supportClinical practiceHF-CSCritical care admissionMulti-disciplinary panelRandomised controlled trialsClinical guidelinesAcutely decompensated chronic HFBackgroundObservational dataControlled trialsDecompensated chronic HFAppropriate methodologiesTrial designInternational expertsConclusionThis studyClinical trial designMechanical circulatory supportChronic HFCardiogenic shockClinical trialsAppropriate panelThoracic ultrasoundCirculatory supportLos AngelesPractice
2023
Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction
Fuery M, Leifer E, Samsky M, Sen S, O'Connor C, Fiuzat M, Ezekowitz J, Piña I, Whellan D, Mark D, Felker G, Desai N, Januzzi J, Ahmad T. Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction. JACC Heart Failure 2023, 12: 479-487. PMID: 38127049, DOI: 10.1016/j.jchf.2023.11.007.Peer-Reviewed Original ResearchNT-proBNP measurementsPrimary trial endpointChronic heart failureNT-proBNP levelsReduced ejection fractionTrial endpointsHeart failureEjection fractionN-terminal pro-B-type natriuretic peptide (NT-proBNP) measurementBaseline NT-proBNP levelsChronic heart failure patientsNT-proBNP monitoringSecondary trial endpointsHeart failure hospitalizationNatriuretic peptide measurementHeart failure patientsCardiovascular deathFailure hospitalizationNT-proBNPFailure patientsPrognostic impactClinical outcomesPrognostic valueOutpatient sitesClinical studiesSafety of sodium‐glucose cotransporter 2 inhibitors drugs among heart failure patients: a systematic review and meta‐analysis
Soleimani H, Saeedian B, Pasebani Y, Babajani N, Yeganeh A, Bahirai P, Navid H, Amin A, Samsky M, Nanna M, Hosseini K. Safety of sodium‐glucose cotransporter 2 inhibitors drugs among heart failure patients: a systematic review and meta‐analysis. ESC Heart Failure 2023, 11: 637-648. PMID: 38124239, PMCID: PMC10966218, DOI: 10.1002/ehf2.14633.Peer-Reviewed Original ResearchIs There a Role for Risk Scores in the Management of Heart Failure? ∗
Abou Alaiwi S, Samsky M, Ahmad T. Is There a Role for Risk Scores in the Management of Heart Failure? ∗. JACC Heart Failure 2023, 12: 197-198. PMID: 38069995, DOI: 10.1016/j.jchf.2023.10.007.Peer-Reviewed Original ResearchStandardized Definitions for Cardiogenic Shock Research and Mechanical Circulatory Support Devices: Scientific Expert Panel From the Shock Academic Research Consortium (SHARC)
Waksman R, Pahuja M, van Diepen S, Proudfoot A, Morrow D, Spitzer E, Nichol G, Weisfeldt M, Moscucci M, Lawler P, Mebazaa A, Fan E, Dickert N, Samsky M, Kormos R, Piña I, Zuckerman B, Farb A, Sapirstein J, Simonton C, West N, Damluji A, Gilchrist I, Zeymer U, Thiele H, Cutlip D, Krucoff M, Abraham W. Standardized Definitions for Cardiogenic Shock Research and Mechanical Circulatory Support Devices: Scientific Expert Panel From the Shock Academic Research Consortium (SHARC). Circulation 2023, 148: 1113-1126. PMID: 37782695, PMCID: PMC11025346, DOI: 10.1161/circulationaha.123.064527.Peer-Reviewed Original ResearchElectronic health record alerts for management of heart failure with reduced ejection fraction in hospitalized patients: the PROMPT-AHF trial
Ghazi L, Yamamoto Y, Fuery M, O'Connor K, Sen S, Samsky M, Riello R, Dhar R, Huang J, Olufade T, McDermott J, Inzucchi S, Velazquez E, Wilson F, Desai N, Ahmad T. Electronic health record alerts for management of heart failure with reduced ejection fraction in hospitalized patients: the PROMPT-AHF trial. European Heart Journal 2023, 44: 4233-4242. PMID: 37650264, DOI: 10.1093/eurheartj/ehad512.Peer-Reviewed Original ResearchGuideline-directed medical therapyAcute heart failureMineralocorticoid receptor antagonistsHeart failureElectronic health recordsGDMT prescriptionPrimary outcomeEnzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitorsSodium-glucose cotransporter 2 inhibitorsAngiotensin receptor neprilysin inhibitorElectronic health record alertsEvidence-based regimenProviders of patientsReduced ejection fractionCotransporter 2 inhibitorsRelevant patient characteristicsTime of dischargePre-specified criteriaAHF hospitalizationEligible patientsInpatient initiationPatient characteristicsEjection fractionHospitalized patientsMedian ageElectronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure
Fuery M, Kadhim B, Samsky M, Freeman J, Clark K, Desai N, Wilson F, Ahmed T, Ahmad T. Electronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure. Current Heart Failure Reports 2023, 20: 280-286. PMID: 37552356, DOI: 10.1007/s11897-023-00614-0.Peer-Reviewed Original ResearchConceptsHeart failure patientsFailure patientsElectronic health recordsEHR alertClinical trialsRandomized clinical trialsCare of patientsQuality of careHeart failureClinician satisfactionRandomized fashionRecent FindingsTherePatientsUnmet needPatient careClinical decisionEvidence-based decisionsFuture interventionsCareHealth recordsTrialsCliniciansInterventionFindingsTherePatient Perspectives on Digital Interventions to Manage Heart Failure Medications: The VITAL-HF Pilot
Samsky M, Leverty R, Gray J, Davis A, Fisher B, Govil A, Stanis T, DeVore A. Patient Perspectives on Digital Interventions to Manage Heart Failure Medications: The VITAL-HF Pilot. Journal Of Clinical Medicine 2023, 12: 4676. PMID: 37510791, PMCID: PMC10380884, DOI: 10.3390/jcm12144676.Peer-Reviewed Original Research