1998
Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure
Oliveto A, Rosen M, Kosten T, Hameedi F, Woods S, Kosten T. Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure. Experimental And Clinical Psychopharmacology 1998, 6: 169-178. PMID: 9608349, DOI: 10.1037/1064-1297.6.2.169.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiscrimination LearningDose-Response Relationship, DrugFemaleHumansHydromorphoneMaleMethadoneNaloxoneOpioid-Related DisordersConceptsNaloxone-appropriate respondingNovel-appropriate respondingDose-related increaseNovel-response drug discrimination procedureOpioid-dependent humansDose-related decreaseDrug discrimination procedureHuman laboratory modelOpioid withdrawalDiscrimination procedureNaloxoneHydromorphoneNonhuman dataAppropriate respondingRespondingPlaceboMethadone
1995
Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomography
1994
Buprenorphine: duration of blockade of effects of intramuscular hydromorphone
Rosen M, Wallace E, McMahon T, Pearsall H, Woods S, Price L, Kosten T. Buprenorphine: duration of blockade of effects of intramuscular hydromorphone. Drug And Alcohol Dependence 1994, 35: 141-149. PMID: 7519977, DOI: 10.1016/0376-8716(94)90121-x.Peer-Reviewed Original Research
1992
Cocaine-Associated Panic Attacks in Methadone-Maintained Patients
Rosen M, Kosten T. Cocaine-Associated Panic Attacks in Methadone-Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1992, 18: 57-62. PMID: 1314016, DOI: 10.3109/00952999209001611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgoraphobiaCocaineFemaleHumansMaleMethadoneOpioid-Related DisordersPanic DisorderRisk FactorsSubstance Abuse Treatment CentersSubstance-Related DisordersBuprenorphine for cocaine and opiate dependence.
Kosten T, Rosen M, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacology Bulletin 1992, 28: 15-9. PMID: 1609037.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineClinical Trials as TopicCocaineHumansOpioid-Related DisordersSubstance-Related DisordersConceptsCocaine abuseMixed opioid agonist/antagonistOpioid agonist/antagonistPreliminary human studiesAgonists/antagonistsBuprenorphine treatmentOpioid dependenceMethadone maintenanceClinical trialsConcurrent dependencePreclinical studiesCocaine effectsBuprenorphineHuman studiesPlace preferenceChallenge studiesCocaineMethadoneTreatmentTrialsAbuseDose dependenceOpioidsAntagonistDaily
1991
Buprenorphine: Beyond Methadone?
Rosen M, Kosten T. Buprenorphine: Beyond Methadone? Psychiatric Services 1991, 42: 347-349. PMID: 2050347, DOI: 10.1176/ps.42.4.347.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBuprenorphineCocaineHumansMethadoneOpioid-Related DisordersRisk FactorsSubstance Abuse, IntravenousSubstance-Related DisordersConceptsConnecticut Mental Health CenterHuman immunodeficiency virusPromising new treatmentMental health centersSubstance abuse treatmentDepartment of PsychiatryAbuse of cocaineIntravenous heroinImmunodeficiency virusHealth centersYale University SchoolNew treatmentsAbuse treatmentGuest authorsDrug addictsDr. RosenUniversity SchoolRisk-taking behaviorTreatmentMethadoneResearch UnitHeroinCocaine