1999
Naloxone Challenge in Smokers: Preliminary Evidence of an Opioid Component in Nicotine Dependence
Krishnan-Sarin S, Rosen M, O'Malley S. Naloxone Challenge in Smokers: Preliminary Evidence of an Opioid Component in Nicotine Dependence. JAMA Psychiatry 1999, 56: 663-668. PMID: 10401515, DOI: 10.1001/archpsyc.56.7.663.Peer-Reviewed Original ResearchConceptsEndogenous opioid systemOpioid systemNicotine dependenceOpiate-like withdrawalNicotine-dependent individualsDose-dependent increaseNicotine-dependent subjectsPreliminary evidenceOpioid componentAdrenal axisNaloxone challengeWithdrawal signsCortisol releaseNeuroendocrine parametersNicotine cravingCigarette smokeLong-term exposureCortisol levelsBaseline levelsLow dosesSubjective signsNaloxoneSmokersChallenge proceduresSymptoms
1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original ResearchHydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure
Oliveto A, Rosen M, Kosten T, Hameedi F, Woods S, Kosten T. Hydromorphone–Naloxone Combinations in Opioid-Dependent Humans Under a Naloxone Novel-Response Discrimination Procedure. Experimental And Clinical Psychopharmacology 1998, 6: 169-178. PMID: 9608349, DOI: 10.1037/1064-1297.6.2.169.Peer-Reviewed Original ResearchConceptsNaloxone-appropriate respondingNovel-appropriate respondingDose-related increaseNovel-response drug discrimination procedureOpioid-dependent humansDose-related decreaseDrug discrimination procedureHuman laboratory modelOpioid withdrawalDiscrimination procedureNaloxoneHydromorphoneNonhuman dataAppropriate respondingRespondingPlaceboMethadone
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original ResearchDose Dependent Effects of Yohimbine on Methadone Maintained Patients
Hameedi F, Woods S, Rosen M, Pearsall H, Kosten T. Dose Dependent Effects of Yohimbine on Methadone Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1997, 23: 327-333. PMID: 9143642, DOI: 10.3109/00952999709040950.Peer-Reviewed Original Research
1996
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal
Rosen M, McMahon T, Woods S, Pearsall H, Kosten T. A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. European Journal Of Pharmacology 1996, 307: 251-257. PMID: 8836612, DOI: 10.1016/0014-2999(96)00249-x.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalOpiate withdrawalOpiate-dependent subjectsPre-clinical studiesConsiderable inter-individual variabilityPretreatment 1 hInter-individual variabilityIntramuscular naloxoneDextromethorphanPilot studyWithdrawal measuresPlaceboNaloxoneMethadoneWithdrawalSubjectsDifferent daysRandomized designThe Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal
Rosen M, Pearsall H, Woods S, Kosten T. The Effect of Gamma-Hydroxybutyric Acid on Naloxone-Precipitated Opiate Withdrawal. Neuropsychopharmacology 1996, 14: 187-193. PMID: 8866702, DOI: 10.1016/0893-133x(95)00087-t.Peer-Reviewed Original ResearchMeSH KeywordsAdultGamma-Aminobutyric AcidHumansNaloxoneNarcoticsSubstance Withdrawal SyndromeTime FactorsConceptsGamma-hydroxybutyric acidAnti-withdrawal effectSpontaneous opiate withdrawalOpiate withdrawalDouble-blind challengesNaloxone-precipitated opiate withdrawalGHB administrationGHB pretreatmentIntravenous naloxoneGHB effectsBalanced randomizationNaloxoneGABA metaboliteConsecutive daysWithdrawal measuresSignificant attenuationPrior studiesWithdrawalPretreatmentPlaceboMg/70InpatientsLevorphanolAdministrationEffect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Rosen M, McMahon T, Hameedi F, Pearsall H, Woods S, Kreek M, Kosten T. Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. Journal Of Pharmacology And Experimental Therapeutics 1996, 276: 1128-35. PMID: 8786543.Peer-Reviewed Original ResearchConceptsClonidine pretreatmentOpiate withdrawalAdrenocorticotropic hormone (ACTH) responseDiastolic blood pressureNaloxone-precipitated opiate withdrawalNaloxone challenge testHeroin-dependent subjectsMeasures of withdrawalNasal congestionBlood pressureNew medicationsWithdrawal severityTesting medicationsChallenge testPlasma cortisolHormone responseConsecutive daysPilot studyClonidineMedicationsPositive controlWithdrawalBase linePretreatmentTwo-factor analysis
1995
The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist
Kosten T, DeCaprio J, Rosen M. The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist. Neuropsychopharmacology 1995, 13: 323-333. PMID: 8747757, DOI: 10.1016/0893-133x(95)00065-l.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalDose-related mannerOpiate withdrawalWithdrawal severityN-methyl-D-aspartate (NMDA) receptor systemPartial agonistOverall withdrawal severityGlycinergic agentsPenile groomingWithdrawal signsOpiate detoxificationHA-966NMDA antagonistsRostral medullaGlycine antagonistLow dosePotential treatmentPutative antagonistNMDA channelsClinical useReceptor systemAntagonistTeeth chatterD-cycloserineSeverityOpiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomographyReliability of Sequential Naloxone Challenge Tests
Rosen M, McMahon T, Margolin A, Gill T, Woods S, Pearsall H, Kreek M, Kosten T. Reliability of Sequential Naloxone Challenge Tests. The American Journal Of Drug And Alcohol Abuse 1995, 21: 453-467. PMID: 8561097, DOI: 10.3109/00952999509002710.Peer-Reviewed Original Research