2000
Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1995
Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans.
Oliveto A, Rosen M, Woods S, Kosten T. Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. Journal Of Pharmacology And Experimental Therapeutics 1995, 272: 231-41. PMID: 7815337.Peer-Reviewed Original ResearchConceptsDose-effect curve determinationsPlacebo-appropriate respondingDose-related increaseCocaine-appropriate respondingCocaine-abusing volunteersDose-effect curvesBlood pressureCardiovascular effectsOral doseIntranasal routeIntranasal cocaineCocaine dosesHeart rateTraining doseBenzodiazepine triazolamPlaceboCocaine HClBehavioral effectsCardiovascular measuresCocaineTriazolamSimilar increaseDiscriminative stimulusDoseSubjects