2021
Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase Activity
Liang F, Nagarajan A, Pillai M, Sung P, Kupfer G. Fanci-FANCD2 Promotes Genome Stability and DNA Repair By Down-Regulating BLM Helicase Activity. Blood 2021, 138: 1113. DOI: 10.1182/blood-2021-152218.Peer-Reviewed Original ResearchDNA end resectionReplication forksGenome stabilityDNA repairResection activityRAD51 recruitmentEnd resectionAmino acid deletionBloom syndromeFanconi anemiaMutant cellsFA DNA repair pathwayAcid deletionDNA damageDNA damage hypersensitivityReplication fork collapseBLM helicase activityEfficient DNA repairHolliday junction dissolutionDNA damage repairDNA repair pathwaysRAD51 foci formationDouble Holliday junction dissolutionIsolation of proteinsHU sensitivity
2020
Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation
Olazabal-Herrero A, Green A, Chen X, Sung P, Pillai M, Kupfer G. Binding of FANCD2 to SRSF1 Splicing Factor Prevents Genomic Instability through R Loop Regulation. Blood 2020, 136: 19. DOI: 10.1182/blood-2020-141369.Peer-Reviewed Original ResearchR-loopsFA pathwayGenomic instabilityFanconi anemiaSplicing factorsR-loop metabolismR-loop regulationFA-like phenotypeBasic cellular processesR-loop formationKey regulatory stepNon-canonical roleDNA damaging agentsNon-canonical mechanismFANCD2-FANCIGenome maintenanceFANCD2 monoubiquitinationMRNA exportGenomic sitesCellular processesInsect cellsProcessing proteinsFA phenotypeRNA transcriptionRegulatory step