2021
Privacy-protecting, reliable response data discovery using COVID-19 patient observations
Kim J, Neumann L, Paul P, Day M, Aratow M, Bell D, Doctor J, Hinske L, Jiang X, Kim K, Matheny M, Meeker D, Pletcher M, Schilling L, SooHoo S, Xu H, Zheng K, Ohno-Machado L, Anderson D, Anderson N, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bernstam E, Carter W, Chau N, Choi Y, Covington S, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hu Z, Ir D, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Mou Z, Murphy R, Neumann L, Nguyen N, Niedermayer S, Park E, Perkins A, Post K, Rieder C, Scherer C, Soares A, Soysal E, Tep B, Toy B, Wang B, Wu Z, Zhou Y, Zucker R. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. Journal Of The American Medical Informatics Association 2021, 28: 1765-1776. PMID: 34051088, PMCID: PMC8194878, DOI: 10.1093/jamia/ocab054.Peer-Reviewed Original Research
2020
A systematic literature review of Native American and Pacific Islanders’ perspectives on health data privacy in the United States
Taitingfong R, Bloss C, Triplett C, Cakici J, Garrison N, Cole S, Stoner J, Ohno-Machado L. A systematic literature review of Native American and Pacific Islanders’ perspectives on health data privacy in the United States. Journal Of The American Medical Informatics Association 2020, 27: 1987-1998. PMID: 33063114, PMCID: PMC7727344, DOI: 10.1093/jamia/ocaa235.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2019
Protecting patient privacy in survival analyses
Bonomi L, Jiang X, Ohno-Machado L. Protecting patient privacy in survival analyses. Journal Of The American Medical Informatics Association 2019, 27: 366-375. PMID: 31750926, PMCID: PMC7025359, DOI: 10.1093/jamia/ocz195.Peer-Reviewed Original ResearchConceptsPrivacy protectionPrivacy risksHealthcare applicationsPatient privacyPrivacy protection methodProvable privacy protectionStrong privacy protectionPerson of interestKnowledgeable adversaryDifferential privacySynthetic datasetsFormal modelEpidemiology datasetPrivacyNonparametric survival modelFuture research directionsAdversaryResearch directionsDatasetBiomedical research applicationsFrameworkFrequent sharingResearch applicationsApplicationsSharingFair compute loads enabled by blockchain: sharing models by alternating client and server roles
Kuo T, Gabriel R, Ohno-Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. Journal Of The American Medical Informatics Association 2019, 26: 392-403. PMID: 30892656, PMCID: PMC7787356, DOI: 10.1093/jamia/ocy180.Peer-Reviewed Original Research
2017
Blockchain distributed ledger technologies for biomedical and health care applications
Kuo T, Kim H, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. Journal Of The American Medical Informatics Association 2017, 24: 1211-1220. PMID: 29016974, PMCID: PMC6080687, DOI: 10.1093/jamia/ocx068.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHealth care domainHealth care applicationsBlockchain technologyLedger technologyCare domainFeatures of blockchainBenefits of blockchainCare applicationsFamous BitcoinInformatics researchersBlockchainTechnologyApplicationsCovered topicsBitcoinDomainLatest applicationsPotential challengesDatabasePrerequisites for International Exchanges of Health Information for Record Research: Comparison of Australian, Austrian, Finnish, Swiss, and US Policies.
Suominen H, Müller H, Ohno-Machado L, Salanterä S, Schreier G, Hanlen L. Prerequisites for International Exchanges of Health Information for Record Research: Comparison of Australian, Austrian, Finnish, Swiss, and US Policies. 2017, 245: 1312. PMID: 29295395.Peer-Reviewed Original Research
2015
Comparison of consumers’ views on electronic data sharing for healthcare and research
Kim K, Joseph J, Ohno-Machado L. Comparison of consumers’ views on electronic data sharing for healthcare and research. Journal Of The American Medical Informatics Association 2015, 22: 821-830. PMID: 25829461, PMCID: PMC5009901, DOI: 10.1093/jamia/ocv014.Peer-Reviewed Original ResearchConceptsElectronic data sharingData sharingHealth information exchangeData networksHealth informationTechnology infrastructureInformation exchangePrivacyHealth Insurance PortabilitySharingAccountability ActUse of dataInsurance PortabilitySecurityNetworkInformationHealthcareIndividual controlHealthcare deliveryMere relianceDepth studyPortabilityAccessInfrastructureComparison of consumersGrid multi-category response logistic models
Wu Y, Jiang X, Wang S, Jiang W, Li P, Ohno-Machado L. Grid multi-category response logistic models. BMC Medical Informatics And Decision Making 2015, 15: 10. PMID: 25886151, PMCID: PMC4342889, DOI: 10.1186/s12911-015-0133-y.Peer-Reviewed Original ResearchMeSH KeywordsClinical Decision-MakingConfidentialityHumansInformation DisseminationLogistic ModelsModels, StatisticalConceptsGrid modelLikelihood estimation problemClassification performance evaluationReal data setsGrid computingEstimation problemTypes of modelsGrid computationGrid methodPrivacyResponse modelCentralized modelMulti-center dataSuch decompositionsFit assessmentFitting methodLinear modelPerformance evaluationModel constructionData setsModel assumptionsIndividual observationsPractical solutionComputationResultsSimulation results
2014
Sharing my health data: a survey of data sharing preferences of healthy individuals.
Bell E, Ohno-Machado L, Grando M. Sharing my health data: a survey of data sharing preferences of healthy individuals. AMIA Annual Symposium Proceedings 2014, 2014: 1699-708. PMID: 25954442, PMCID: PMC4419941.Peer-Reviewed Original ResearchChoosing blindly but wisely: differentially private solicitation of DNA datasets for disease marker discovery
Zhao Y, Wang X, Jiang X, Ohno-Machado L, Tang H. Choosing blindly but wisely: differentially private solicitation of DNA datasets for disease marker discovery. Journal Of The American Medical Informatics Association 2014, 22: 100-108. PMID: 25352565, PMCID: PMC4433380, DOI: 10.1136/amiajnl-2014-003043.Peer-Reviewed Original ResearchConceptsData ownersData usersHuman genomic datasetsHuman genomic dataPatient privacyPrivacyGeneration approachUsersData selectionReal dataDatasetGenomic datasetsPrivate solicitationDNA datasetsScientific discoveryNew approachGenomic dataHigh confidencePilot versionEvaluation methodRight choiceOwnersAlgorithmNew techniqueDisease marker discoverypSCANNER: patient-centered Scalable National Network for Effectiveness Research
Ohno-Machado L, Agha Z, Bell D, Dahm L, Day M, Doctor J, Gabriel D, Kahlon M, Kim K, Hogarth M, Matheny M, Meeker D, Nebeker J, team T, Resnic F, Khodyakov D, Armstead L, Nagler T, Morley S, Anderson N, Cooper D, Phillips D, Heber D, Li Z, Ong M, Patel A, Zachariah M, Burns J, Daniels L, Doan S, Farcas C, Germann-Kurtz R, Jiang X, Kim H, Paul P, Taras H, Tremoulet A, Wang S, Zhu W, Berman D, Rizk-Jackson A, D’Arcy M, Kesselman C, Knight T, Pearlman L, Heidenreich P, Rifkin D, Stepnowsky C, Zamora T, DuVall S, Frey L, Scehnet J, Sauer B, Facelli J, Gouripeddi R, Denton J, FitzHenry F, Fly J, Messina V, Minter F, Nookala L, Sullivan H, Speroff T, Westerman D. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. Journal Of The American Medical Informatics Association 2014, 21: 621-626. PMID: 24780722, PMCID: PMC4078293, DOI: 10.1136/amiajnl-2014-002751.Peer-Reviewed Original ResearchConceptsInitial use caseCommon data modelPatient Centered Outcomes Research InstituteHealth information exchange dataComputing infrastructuresFederated networkUse casesDistributed systemData modelComputation modelExchange dataPatient-powered research networksCommunity-based outpatient clinicsNetworkCongestive heart failureOutcomes Research InstituteEffectiveness researchAsynchronous modeHealth services researchersKawasaki diseaseHeart failureOutpatient clinicVA InformaticsAmbulatory careNational network
2013
Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders
Kim K, Browe D, Logan H, Holm R, Hack L, Ohno-Machado L. Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders. Journal Of The American Medical Informatics Association 2013, 21: 714-719. PMID: 24302285, PMCID: PMC4078279, DOI: 10.1136/amiajnl-2013-002308.Peer-Reviewed Original ResearchConceptsFair Information Practice PrinciplesTechnical infrastructureClinical data reuseGovernance requirementsTrustworthy platformData reuseHealth Insurance PortabilityHIPAA regulationsAccountability ActNetworkInsurance PortabilityHealth informationRequirementsInformationResearch NetworkPrivacyPortabilityBest practicesInfrastructurePlatformReuseDiverse stakeholdersTimelinessWebGLORE: a Web service for Grid LOgistic REgression
Jiang W, Li P, Wang S, Wu Y, Xue M, Ohno-Machado L, Jiang X. WebGLORE: a Web service for Grid LOgistic REgression. Bioinformatics 2013, 29: 3238-3240. PMID: 24072732, PMCID: PMC3842761, DOI: 10.1093/bioinformatics/btt559.Peer-Reviewed Original ResearchConceptsWeb servicesHypertext Transfer Protocol SecurePrivacy-preserving constructionFree Software FoundationGNU General Public LicenseUse web serviceFree web serviceGeneral Public LicenseDistributed datasetsTrusted serverProtocol SecureSoftware FoundationPublic LicensePHP technologyInformation exchangeBiomedical researchersLocal statisticsServicesServletsServerSecureAjaxGlobal logistic regression modelDatasetGlobal modelDevelopment of a Privacy and Security Policy Framework for a Multistate Comparative Effectiveness Research Network
Kim K, McGraw D, Mamo L, Ohno-Machado L. Development of a Privacy and Security Policy Framework for a Multistate Comparative Effectiveness Research Network. Medical Care 2013, 51: s66-s72. PMID: 23774516, DOI: 10.1097/mlr.0b013e31829b1d9f.Peer-Reviewed Original ResearchMeSH KeywordsComparative Effectiveness ResearchComputer SecurityConfidentialityHumansMulticenter Studies as TopicPolicyResearch DesignPrivacy Technology to Support Data Sharing for Comparative Effectiveness Research
Jiang X, Sarwate A, Ohno-Machado L. Privacy Technology to Support Data Sharing for Comparative Effectiveness Research. Medical Care 2013, 51: s58-s65. PMID: 23774511, PMCID: PMC3728160, DOI: 10.1097/mlr.0b013e31829b1d10.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsComparative Effectiveness ResearchConfidentialityCooperative BehaviorDatabases, BibliographicHumansSoftwareConceptsData sharingPrivacy-preserving data sharingPrivacy-preserving technologiesEffective data sharingPrivacy technologiesData miningNetwork dataData typesThird-party expertsData tablesSpecific scenariosSharingInappropriate disclosurePractical evaluationPractical impactPatient dataNew technologiesTechnologyPrivacyComparative effectiveness researchMiningPractical toolCER studiesTextTime seriesSharing data for the public good and protecting individual privacy: informatics solutions to combine different goals
Ohno-Machado L. Sharing data for the public good and protecting individual privacy: informatics solutions to combine different goals. Journal Of The American Medical Informatics Association 2013, 20: 1-1. PMID: 23243087, PMCID: PMC3555342, DOI: 10.1136/amiajnl-2012-001513.Commentaries, Editorials and Letters
2012
Privacy-preserving heterogeneous health data sharing
Mohammed N, Jiang X, Chen R, Fung B, Ohno-Machado L. Privacy-preserving heterogeneous health data sharing. Journal Of The American Medical Informatics Association 2012, 20: 462-469. PMID: 23242630, PMCID: PMC3628047, DOI: 10.1136/amiajnl-2012-001027.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsConfidentialityData MiningDatabases, FactualFemaleHumansInformation DisseminationMalePrivacyConceptsSet-valued dataDifferential privacyNoise additionPrivacy-preserving mannerAdversary's background knowledgeStrong privacy guaranteesBackground knowledgeHealth data sharingPrivacy modelPrivacy guaranteesSensitive dataData sharingHealthcare dataPrivate mannerAlgorithm designPrivacyRaw dataSynthetic dataAlgorithmHealth dataProbabilistic wayDiscriminative analysisExperimental resultsUseful informationClassification analysisA collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning.
Que J, Jiang X, Ohno-Machado L. A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning. AMIA Annual Symposium Proceedings 2012, 2012: 1350-9. PMID: 23304414, PMCID: PMC3540462.Peer-Reviewed Original ResearchConceptsSupport vector machineVector machinePrivacy-preserving collaborative learningSensitive raw dataPrivacy-preserving mannerEfficient information exchangeDistributed PrivacyLocal repositoryPrivacy concernsCentralized repositoryCollaborative frameworkDecision supportMultiple participantsInformation exchangeRaw dataSVM modelIntermediary resultsMachineCollaborative learningPrivacyPopular toolRepositoryTraditional wayPatient dataServerPreserving Institutional Privacy in Distributed binary Logistic Regression.
Wu Y, Jiang X, Ohno-Machado L. Preserving Institutional Privacy in Distributed binary Logistic Regression. AMIA Annual Symposium Proceedings 2012, 2012: 1450-8. PMID: 23304425, PMCID: PMC3540539.Peer-Reviewed Original ResearchSHARE: system design and case studies for statistical health information release
Gardner J, Xiong L, Xiao Y, Gao J, Post A, Jiang X, Ohno-Machado L. SHARE: system design and case studies for statistical health information release. Journal Of The American Medical Informatics Association 2012, 20: 109-116. PMID: 23059729, PMCID: PMC3555328, DOI: 10.1136/amiajnl-2012-001032.Peer-Reviewed Original ResearchConceptsDifferential privacy frameworkPrivacy frameworkDifferential privacyMultidimensional histogramsReal medical datasetsMedical data warehouseOriginal data distributionInformation releaseHigh-dimensional dataBreast cancer datasetPattern queriesMedical datasetsElectronic medical record datasetHeterogeneous dataData warehouseUse casesElectronic health recordsMedical domainBiomedical dataThree-dimensional data cubeArt methodsData distributionMedical dataDimensional dataData cube