2021
Privacy-protecting, reliable response data discovery using COVID-19 patient observations
Kim J, Neumann L, Paul P, Day M, Aratow M, Bell D, Doctor J, Hinske L, Jiang X, Kim K, Matheny M, Meeker D, Pletcher M, Schilling L, SooHoo S, Xu H, Zheng K, Ohno-Machado L, Anderson D, Anderson N, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bernstam E, Carter W, Chau N, Choi Y, Covington S, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hu Z, Ir D, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Mou Z, Murphy R, Neumann L, Nguyen N, Niedermayer S, Park E, Perkins A, Post K, Rieder C, Scherer C, Soares A, Soysal E, Tep B, Toy B, Wang B, Wu Z, Zhou Y, Zucker R. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. Journal Of The American Medical Informatics Association 2021, 28: 1765-1776. PMID: 34051088, PMCID: PMC8194878, DOI: 10.1093/jamia/ocab054.Peer-Reviewed Original Research
2020
EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning
Kuo T, Gabriel R, Cidambi K, Ohno-Machado L. EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare/genomics predictive model learning. Journal Of The American Medical Informatics Association 2020, 27: 747-756. PMID: 32364235, PMCID: PMC7309256, DOI: 10.1093/jamia/ocaa023.Peer-Reviewed Original ResearchConceptsBlockchain technologyCentral serverServer-based methodBenefits of blockchainData protection policiesCentralized serverArtificial intelligenceModel learningDecentralized approachSmall datasetsBlockchainServerComputation strategySingle pointGeneralizable modelCost of efficiencyGenomic datasetsDatasetDistributed modelTechnologyGenomic dataMultiple institutionsDiscrimination powerIntelligencePotential advantages/disadvantages
2019
Fair compute loads enabled by blockchain: sharing models by alternating client and server roles
Kuo T, Gabriel R, Ohno-Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. Journal Of The American Medical Informatics Association 2019, 26: 392-403. PMID: 30892656, PMCID: PMC7787356, DOI: 10.1093/jamia/ocy180.Peer-Reviewed Original Research
2015
WebDISCO: a web service for distributed cox model learning without patient-level data sharing
Lu C, Wang S, Ji Z, Wu Y, Xiong L, Jiang X, Ohno-Machado L. WebDISCO: a web service for distributed cox model learning without patient-level data sharing. Journal Of The American Medical Informatics Association 2015, 22: 1212-1219. PMID: 26159465, PMCID: PMC5009917, DOI: 10.1093/jamia/ocv083.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer Communication NetworksDatasets as TopicDecision Support Systems, ClinicalHumansInformation DisseminationInternetProportional Hazards ModelsSurvival AnalysisA system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research
Meeker D, Jiang X, Matheny M, Farcas C, D’Arcy M, Pearlman L, Nookala L, Day M, Kim K, Kim H, Boxwala A, El-Kareh R, Kuo G, Resnic F, Kesselman C, Ohno-Machado L. A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research. Journal Of The American Medical Informatics Association 2015, 22: 1187-1195. PMID: 26142423, PMCID: PMC4639714, DOI: 10.1093/jamia/ocv017.Peer-Reviewed Original ResearchConceptsFederated networkData sharing policiesParallel computation methodSharing policiesPolicy management systemData exchange policiesData storage requirementsWeb servicesNetwork queriesQuery functionalityComputation resourcesFederated modelGraphical interfaceData transportCentralized networkStorage requirementsNetwork participantsManagement systemQueriesNetworkComputation methodNew featuresMultivariate statistical estimationDifferent state lawsImportant new feature
2014
Networking the country to promote health and scientific discovery
Ohno-Machado L. Networking the country to promote health and scientific discovery. Journal Of The American Medical Informatics Association 2014, 21: 575-575. PMID: 24908676, PMCID: PMC4078300, DOI: 10.1136/amiajnl-2014-003005.Peer-Reviewed Original ResearchComputer Communication NetworksElectronic Health RecordsHumansOutcome Assessment, Health CarePatient-Centered CareUnited StatespSCANNER: patient-centered Scalable National Network for Effectiveness Research
Ohno-Machado L, Agha Z, Bell D, Dahm L, Day M, Doctor J, Gabriel D, Kahlon M, Kim K, Hogarth M, Matheny M, Meeker D, Nebeker J, team T, Resnic F, Khodyakov D, Armstead L, Nagler T, Morley S, Anderson N, Cooper D, Phillips D, Heber D, Li Z, Ong M, Patel A, Zachariah M, Burns J, Daniels L, Doan S, Farcas C, Germann-Kurtz R, Jiang X, Kim H, Paul P, Taras H, Tremoulet A, Wang S, Zhu W, Berman D, Rizk-Jackson A, D’Arcy M, Kesselman C, Knight T, Pearlman L, Heidenreich P, Rifkin D, Stepnowsky C, Zamora T, DuVall S, Frey L, Scehnet J, Sauer B, Facelli J, Gouripeddi R, Denton J, FitzHenry F, Fly J, Messina V, Minter F, Nookala L, Sullivan H, Speroff T, Westerman D. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. Journal Of The American Medical Informatics Association 2014, 21: 621-626. PMID: 24780722, PMCID: PMC4078293, DOI: 10.1136/amiajnl-2014-002751.Peer-Reviewed Original ResearchConceptsInitial use caseCommon data modelPatient Centered Outcomes Research InstituteHealth information exchange dataComputing infrastructuresFederated networkUse casesDistributed systemData modelComputation modelExchange dataPatient-powered research networksCommunity-based outpatient clinicsNetworkCongestive heart failureOutcomes Research InstituteEffectiveness researchAsynchronous modeHealth services researchersKawasaki diseaseHeart failureOutpatient clinicVA InformaticsAmbulatory careNational network
2013
Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders
Kim K, Browe D, Logan H, Holm R, Hack L, Ohno-Machado L. Data governance requirements for distributed clinical research networks: triangulating perspectives of diverse stakeholders. Journal Of The American Medical Informatics Association 2013, 21: 714-719. PMID: 24302285, PMCID: PMC4078279, DOI: 10.1136/amiajnl-2013-002308.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchComputer Communication NetworksComputer SecurityConfidentialityHealth Insurance Portability and Accountability ActModels, OrganizationalUnited StatesConceptsFair Information Practice PrinciplesTechnical infrastructureClinical data reuseGovernance requirementsTrustworthy platformData reuseHealth Insurance PortabilityHIPAA regulationsAccountability ActNetworkInsurance PortabilityHealth informationRequirementsInformationResearch NetworkPrivacyPortabilityBest practicesInfrastructurePlatformReuseDiverse stakeholdersTimelinessWebGLORE: a Web service for Grid LOgistic REgression
Jiang W, Li P, Wang S, Wu Y, Xue M, Ohno-Machado L, Jiang X. WebGLORE: a Web service for Grid LOgistic REgression. Bioinformatics 2013, 29: 3238-3240. PMID: 24072732, PMCID: PMC3842761, DOI: 10.1093/bioinformatics/btt559.Peer-Reviewed Original ResearchMeSH KeywordsArea Under CurveBiomedical ResearchComputer Communication NetworksConfidentialityCooperative BehaviorHumansInformation DisseminationInternetLogistic ModelsSoftwareSupport Vector MachineConceptsWeb servicesHypertext Transfer Protocol SecurePrivacy-preserving constructionFree Software FoundationGNU General Public LicenseUse web serviceFree web serviceGeneral Public LicenseDistributed datasetsTrusted serverProtocol SecureSoftware FoundationPublic LicensePHP technologyInformation exchangeBiomedical researchersLocal statisticsServicesServletsServerSecureAjaxGlobal logistic regression modelDatasetGlobal model
2012
A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning.
Que J, Jiang X, Ohno-Machado L. A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning. AMIA Annual Symposium Proceedings 2012, 2012: 1350-9. PMID: 23304414, PMCID: PMC3540462.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceComputer Communication NetworksConfidentialityCooperative BehaviorDecision Support TechniquesHumansInternetPrivacyProgramming LanguagesSupport Vector MachineConceptsSupport vector machineVector machinePrivacy-preserving collaborative learningSensitive raw dataPrivacy-preserving mannerEfficient information exchangeDistributed PrivacyLocal repositoryPrivacy concernsCentralized repositoryCollaborative frameworkDecision supportMultiple participantsInformation exchangeRaw dataSVM modelIntermediary resultsMachineCollaborative learningPrivacyPopular toolRepositoryTraditional wayPatient dataServer
2010
DSGeo: Software tools for cross-platform analysis of gene expression data in GEO
Lacson R, Pitzer E, Kim J, Galante P, Hinske C, Ohno-Machado L. DSGeo: Software tools for cross-platform analysis of gene expression data in GEO. Journal Of Biomedical Informatics 2010, 43: 709-715. PMID: 20435161, PMCID: PMC2934864, DOI: 10.1016/j.jbi.2010.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsComputational BiologyComputer Communication NetworksGene Expression ProfilingHumansInformation Storage and RetrievalMedical Informatics ApplicationsSoftwareUser-Computer InterfaceConceptsAggregation of dataData loaderRelational databaseGene expression dataUser preferencesData browserData browsingCross-platform dataSoftware toolsSeamless integrationCross-platform analysisGroups of dataQueriesExpression dataPublic gene expression dataSpecific sample characteristicsLarge resourcesBrowserToolBrowsingAnnotatingUsersRetrievalApplicationsPlatform
2007
SMART—An Integrated Wireless System for Monitoring Unattended Patients
Curtis D, Pino E, Bailey J, Shih E, Waterman J, Vinterbo S, Stair T, Guttag J, Greenes R, Ohno-Machado L. SMART—An Integrated Wireless System for Monitoring Unattended Patients. Journal Of The American Medical Informatics Association 2007, 15: 44-53. PMID: 17947629, PMCID: PMC2274866, DOI: 10.1197/jamia.m2016.Peer-Reviewed Original ResearchMeSH KeywordsComputer Communication NetworksComputers, HandheldDisaster MedicineEquipment DesignHumansMonitoring, AmbulatoryPilot ProjectsSystems IntegrationTelecommunicationsTelemetry
1997
A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database.
Ohno-Machado L, Boxwala A, Ehresman J, Smith D, Greenes R. A virtual repository approach to clinical and utilization studies: application in mammography as alternative to a national database. AMIA Annual Symposium Proceedings 1997, 369-73. PMID: 9357650, PMCID: PMC2233552.Peer-Reviewed Original ResearchConceptsMammography databaseVisualization of resultsHeterogeneous databasesFederated databasesCentralized architectureExploratory analysis toolLegacy systemsCommon queriesPrototype systemQueriesVirtual repositoryAlternative architecturesImmediate displayDifferent databasesArchitectureAnalysis toolsMammography dataUse of dataRepositoryMammography reportsDatabaseUsersDownloadSystemVisualization