2022
Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort
Nagar S, Pemu P, Qian J, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Ramirez A, Schully S, Able A, Green A, Zuchner S, Jordan I, Meller R. Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort. Scientific Reports 2022, 12: 19797. PMID: 36396674, PMCID: PMC9672061, DOI: 10.1038/s41598-022-23353-z.Peer-Reviewed Original ResearchConceptsAssociation of hypertensionPrevalence of dementiaType 2 diabetesRisk factorsUS populationRace/ethnicityHigh prevalenceLarge observational cohort studyMultivariable logistic regression modelRisk factor modificationObservational cohort studyT2D risk factorsInvestigation of hypertensionAssociation of T2DOdds of dementiaRace/ethnicity groupsAssociation of sexCross-sectional analysisLogistic regression modelsWorld Health OrganizationElectronic health recordsConcurrent hypertensionModifiable comorbiditiesCohort studyFinal cohort
2019
Time Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice
Baxter S, Gali H, Huang A, Millen M, El-Kareh R, Nudleman E, Robbins S, Heichel C, Camp A, Korn B, Lee J, Kikkawa D, Longhurst C, Chiang M, Hribar M, Ohno-Machado L. Time Requirements of Paper-Based Clinical Workflows and After-Hours Documentation in a Multispecialty Academic Ophthalmology Practice. American Journal Of Ophthalmology 2019, 206: 161-167. PMID: 30910517, PMCID: PMC6755078, DOI: 10.1016/j.ajo.2019.03.014.Peer-Reviewed Original ResearchConceptsPatient encountersNew patient evaluationsClinical workflowElectronic health record useOutpatient ophthalmology clinicHigh clinical volumeAcademic ophthalmology departmentsAcademic ophthalmology practicePaper-based documentationAge 43.9Postoperative visitRoutine followClinic hoursOphthalmology clinicOphthalmology departmentPatient evaluationOphthalmology practiceOutcome measurementsPatientsPatient careHours workRecord useOphthalmologistsClinical volumeTotal time
2017
A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries
Gabriel R, Waterman R, Kim J, Ohno-Machado L. A Predictive Model for Extended Postanesthesia Care Unit Length of Stay in Outpatient Surgeries. Anesthesia & Analgesia 2017, 124: 1529-1536. PMID: 28079580, DOI: 10.1213/ane.0000000000001827.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAmbulatory Surgical ProceduresAnesthesiaChildChild, PreschoolCritical CareFemaleForecastingHumansHypertensionInfantInfant, NewbornIntensive Care UnitsLength of StayLogistic ModelsMaleMiddle AgedModels, StatisticalObesity, MorbidPostoperative CareRisk FactorsROC CurveYoung AdultConceptsPACU lengthPostanesthesia care unit lengthPrimary anesthesia typePostanesthesia care unitHosmer-Lemeshow testLogistic regression modelsAnesthesia typeMorbid obesityCare unitHL testOutpatient surgeryOutpatient procedureSingle institutionHigher oddsNonsignificant P valuesStayPatientsSurgical specialtiesROC curveGood calibrationCharacteristic curveExcellent discriminationAUC valuesP-valueBackward elimination
2013
Differential Expression of miR-145 in Children with Kawasaki Disease
Shimizu C, Kim J, Stepanowsky P, Trinh C, Lau H, Akers J, Chen C, Kanegaye J, Tremoulet A, Ohno-Machado L, Burns J. Differential Expression of miR-145 in Children with Kawasaki Disease. PLOS ONE 2013, 8: e58159. PMID: 23483985, PMCID: PMC3590129, DOI: 10.1371/journal.pone.0058159.Peer-Reviewed Original ResearchMeSH KeywordsArteriesBase SequenceChildChild, PreschoolCluster AnalysisGene Expression RegulationHumansInfantMicroRNAsModels, BiologicalMolecular Sequence DataMucocutaneous Lymph Node SyndromeReal-Time Polymerase Chain ReactionSequence AlignmentSequence Analysis, DNASignal TransductionTransforming Growth Factor betaConceptsTGF-β pathwayGene expressionMiR-145Small non-coding RNAsKawasaki disease pathogenesisExtracellular vesiclesSmall RNA speciesPost-transcriptional levelDiscovery of microRNAsKawasaki diseaseNon-coding RNAsExpression of genesDisease pathogenesisSmall extracellular vesiclesSmall RNAsRNA speciesTarget genesTop pathwaysVascular smooth muscle cellsPathway analysisDifferentiation of neutrophilsDifferential expressionMicroRNAsArterial wallGeneration of myofibroblasts
2002
Open source handheld-based EMR for paramedics working in rural areas.
Anantraman V, Mikkelsen T, Khilnani R, Kumar V, Pentland A, Ohno-Machado L. Open source handheld-based EMR for paramedics working in rural areas. AMIA Annual Symposium Proceedings 2002, 12-6. PMID: 12463777, PMCID: PMC2244537.Peer-Reviewed Original Research
2000
Decision trees and fuzzy logic: a comparison of models for the selection of measles vaccination strategies in Brazil.
Ohno-Machado L, Lacson R, Massad E. Decision trees and fuzzy logic: a comparison of models for the selection of measles vaccination strategies in Brazil. AMIA Annual Symposium Proceedings 2000, 625-9. PMID: 11079959, PMCID: PMC2244038.Peer-Reviewed Original Research
1993
Prognostic classification for aids patients in Brazil
Ohno-Machado L. Prognostic classification for aids patients in Brazil. Journal Of Medical Systems 1993, 17: 163-172. PMID: 8254260, DOI: 10.1007/bf00996941.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAgedAIDS-Related Opportunistic InfectionsBrazilCause of DeathChildChild, PreschoolCross-Sectional StudiesDeveloping CountriesDiscriminant AnalysisFemaleHospitalizationHumansIncidenceInfantInfant, NewbornMaleMiddle AgedNeoplasmsSurvival RateConceptsHospitalized AIDS patientsPrognosis of deathHistory of transfusionGroup IV patientsNumber of infectionsEsophageal candidiasisIV patientsAIDS patientsFirst manifestationAID patientsRisk groupsPrognostic classificationPrognostic variablesSurvival ratePatientsFinal discriminant functionInfectionDiseaseDeathAnalysis groupHospitalizationTransfusionPrognosisGroupCandidiasis