2017
MiRIAD update: using alternative polyadenylation, protein interaction network analysis and additional species to enhance exploration of the role of intragenic miRNAs and their host genes
Hinske L, dos Santos F, Ohara D, Ohno-Machado L, Kreth S, Galante P. MiRIAD update: using alternative polyadenylation, protein interaction network analysis and additional species to enhance exploration of the role of intragenic miRNAs and their host genes. Database 2017, 2017: bax053. PMID: 29220447, PMCID: PMC5569676, DOI: 10.1093/database/bax053.Peer-Reviewed Original Research
2014
miRIAD—integrating microRNA inter- and intragenic data
Hinske L, França G, Torres H, Ohara D, Lopes-Ramos C, Heyn J, Reis L, Ohno-Machado L, Kreth S, Galante P. miRIAD—integrating microRNA inter- and intragenic data. Database 2014, 2014: bau099. PMID: 25288656, PMCID: PMC4186326, DOI: 10.1093/database/bau099.Peer-Reviewed Original ResearchConceptsProtein-coding genesIntragenic miRNAsHost genesGene expressionProtein-protein interaction dataSmall non-coding RNAsHost gene functionHost gene expressionMiRNA binding sitesNon-coding RNAsMajority of miRNAsGene functionGenomic contextFunctional annotationFunctional network analysisTarget mRNAsExpression correlationExonic regionsGenesMiRNAsDifferent tissuesInteraction dataBinding sitesGenomic classificationSilico validation
2010
A potential role for intragenic miRNAs on their hosts' interactome
Hinske L, Galante P, Kuo W, Ohno-Machado L. A potential role for intragenic miRNAs on their hosts' interactome. BMC Genomics 2010, 11: 533. PMID: 20920310, PMCID: PMC3091682, DOI: 10.1186/1471-2164-11-533.Peer-Reviewed Original ResearchConceptsIntragenic miRNAsHost genesAdenylate/uridylate-rich elementsMiRNA targetsMRNA targetsHost interactomeGene cohortsMiRNA biogenesis pathwayNon-coding RNA moleculesHigh-confidence setMiRNA target genesProtein-coding regionsKEGG pathway analysisTight regulatory controlNegative feedback regulatorIntronic miRNAsMore intronsBiogenesis pathwayMiRNA genesNegative feedback loopUridylate-rich elementsCellular homeostasisTarget genesRNA moleculesInteractome