2021
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding
Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. The American Journal Of Gastroenterology 2021, 116: 899-917. PMID: 33929377, DOI: 10.14309/ajg.0000000000001245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUpper gastrointestinal bleedingEndoscopic therapyGastrointestinal bleedingHigh-dose proton pump inhibitor therapyOvert upper gastrointestinal bleedingOral proton pump inhibitorsProton pump inhibitor therapyRed blood cell transfusionAbsolute ethanol injectionWeeks of therapyBlood cell transfusionLow-quality evidenceLow-risk patientsManagement of patientsProton pump inhibitorsArgon plasma coagulationActive spurtingErythromycin infusionTC-325Cell transfusionRecurrent bleedingRecurrent ulcersUlcer bleedingEndoscopic hemostasisGRADE approach
2008
Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials
Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.Peer-Reviewed Original ResearchConceptsEndoscopic therapyProton pump inhibitorsActive bleedingVisible vesselPump inhibitorsIntravenous proton pump inhibitorsAppropriate endoscopic treatmentNonbleeding visible vesselPrimary end pointSecond-look endoscopyEndoscopic hemostatic therapyRandomized Controlled TrialsEvidence-based approachPlacebo/Further bleedingHemostatic therapyInjection therapyControlled TrialsEndoscopic treatmentRandomized trialsBleeding ulcersSclerosant therapyReceptor antagonistBibliographic database searchBleedingOptimizing bipolar electrocoagulation for endoscopic hemostasis: assessment of factors influencing energy delivery and coagulation
Laine L, Long GL, Bakos GJ, Vakharia OJ, Cunningham C. Optimizing bipolar electrocoagulation for endoscopic hemostasis: assessment of factors influencing energy delivery and coagulation. Gastrointestinal Endoscopy 2008, 67: 502-508. PMID: 18294513, DOI: 10.1016/j.gie.2007.09.025.Peer-Reviewed Original Research
2002
Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough?
Laine L, Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough? Gastrointestinal Endoscopy 2002, 55: 6-10. PMID: 11756906, DOI: 10.1067/mge.2002.120390.Peer-Reviewed Original ResearchConceptsSaline solution injectionSaline solution groupNormal saline solutionBipolar electrocoagulationLocal tamponadeNonbleeding visible vesselIndependent risk factorSolution injectionSolution groupTreatment of patientsSaline solutionMajor bleedingActive bleedingEndoscopic injectionHospital daysStandard therapyUlcer sizeLack of injuryClinical evidenceVisible vesselRisk factorsEffective treatmentPatientsBleedingUlcers
1993
Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids
Yang R, Migikovsky B, Peicher J, Laine L. Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids. Gastrointestinal Endoscopy 1993, 39: 766-769. PMID: 8293898, DOI: 10.1016/s0016-5107(93)70261-8.Peer-Reviewed Original ResearchConceptsBipolar electrocoagulation groupElectrocoagulation groupBipolar electrocoagulationInternal hemorrhoidsTreatment groupsTreatment sessionsStandard medical therapyHaemorrhoid gradeProcedural painProspective trialMedical therapyRectal ulcerationUncontrollable bleedingHemorrhoidsRate of successPainTherapyPatientsGroupSessionsBleedingDirect current electrocoagulationUlcerationObliterationTrials
1992
Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis
Cook D, Guyatt G, Salena B, Laine L. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Gastroenterology 1992, 102: 139-148. PMID: 1530782, DOI: 10.1016/0016-5085(92)91793-4.Peer-Reviewed Original ResearchConceptsAcute nonvariceal upper gastrointestinal hemorrhageNonvariceal upper gastrointestinal hemorrhageUpper gastrointestinal hemorrhageEndoscopic hemostatic therapyEndoscopic therapyGastrointestinal hemorrhageHemostatic therapyEndoscopic treatmentFlat pigmented spotUpper gastrointestinal bleedingDuplicate independent reviewForm of therapyEnglish-language literatureActive bleedingFurther bleedingGastrointestinal bleedingEndoscopic featuresInjection therapyAdherent clotRelevant trialsSurgery ratesVisible vesselLaser therapyBleedingTherapy
1991
Determination of the optimal technique for bipolar electrocoagulation treatment An experimental evaluation of the BICAP and Gold probes
Laine L. Determination of the optimal technique for bipolar electrocoagulation treatment An experimental evaluation of the BICAP and Gold probes. Gastroenterology 1991, 100: 107-112. PMID: 1983812, DOI: 10.1016/0016-5085(91)90589-d.Peer-Reviewed Original Research
1990
Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial
Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial. Gastroenterology 1990, 99: 1303-1306. PMID: 2210238, DOI: 10.1016/0016-5085(90)91154-x.Peer-Reviewed Original ResearchConceptsNonbleeding visible vesselMultipolar electrocoagulationInjection therapyVisible vesselEndoscopic evidenceActive bleedingBloody nasogastric aspirateUpper gastrointestinal bleedHigh-risk patientsUnstable vital signsIncidence of surgeryTreatment of patientsCost of hospitalizationUnits of bloodFurther bleedingGastrointestinal bleedHospital stayNasogastric aspirateClinical evidencePeptic ulcerComparable efficacyMortality ratePatientsBleedingUlcers
1989
Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels. A prospective, controlled trial.
Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels. A prospective, controlled trial. Annals Of Internal Medicine 1989, 110: 510-4. PMID: 2647014, DOI: 10.7326/0003-4819-110-7-510.Peer-Reviewed Original ResearchConceptsNonbleeding visible vesselMultipolar electrocoagulationVisible vesselControl groupMajor upper gastrointestinal hemorrhageMean transfusion requirementSham-controlled trialUpper gastrointestinal hemorrhageUnstable vital signsSafety of treatmentCost of hospitalizationUnits of bloodEndoscopic evidenceGastrointestinal hemorrhageTransfusion requirementsUrgent surgeryEmergency surgeryHospital daysEndoscopic treatmentOverall mortalityPeptic ulcerCounty HospitalAspirate samplesDiagnostic endoscopyTreatment groups
1987
Multipolar Electrocoagulation in the Treatment of Active Upper Gastrointestinal Tract Hemorrhage
Laine L. Multipolar Electrocoagulation in the Treatment of Active Upper Gastrointestinal Tract Hemorrhage. New England Journal Of Medicine 1987, 316: 1613-1617. PMID: 3295547, DOI: 10.1056/nejm198706253162601.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal tract hemorrhageUpper gastrointestinal hemorrhageGastrointestinal tract hemorrhageMultipolar electrocoagulationGastrointestinal hemorrhageTract hemorrhageActive upper gastrointestinal hemorrhageNonvariceal upper gastrointestinal hemorrhageBloody nasogastric aspirateTerms of hemostasisMallory-Weiss tearUnstable vital signsUnits of bloodTransfusion requirementsActive bleedingHospital courseEmergency surgeryHospital daysNasogastric aspirateNonsurgical therapyVascular malformationsMean costHemorrhagePatientsVital signs