2022
Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2020
Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLeptin levelsCerebrospinal fluidLean mothersPlasma ratioMaternal cerebrospinal fluidMaternal metabolic environmentElective cesarean deliveryImpact of obesityCord blood insulinEffect of diabetesLow cerebrospinal fluidUncomplicated singleton pregnanciesMaternal plasma ratioArtery plasmaDM mothersCesarean deliveryObese patientsSingleton pregnanciesFetal exposureBlood insulinLower cordPregnant womenMaternal brainLean individuals
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1
2018
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia
Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Journal Of Clinical Investigation 2018, 128: 1485-1495. PMID: 29381484, PMCID: PMC5873861, DOI: 10.1172/jci97696.Peer-Reviewed Original ResearchConceptsMild hypoglycemiaHypoglycemia awarenessType 1 diabetes mellitus patientsPrefrontal cortexHormonal counterregulatory responsesDiabetes mellitus patientsImpaired hypoglycemia awarenessAltered activation patternsAngular gyrusType 1 diabetesBlood glucose levelsHypoglycemia-induced changesBrain responsesBrain activityHypoglycemia symptom scoresAlters brain activityClinical Translational Science AwardsHyperinsulinemic euglycemicHypoglycemia unawarenessCounterregulatory responsesHypoglycemic clampMellitus patientsMRI brainSymptom scoresNondiabetic individuals
2017
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM
Hwang JJ, Jiang L, Hamza M, Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2: e95913. PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.Peer-Reviewed Original ResearchConceptsGlucose levelsPlasma free fatty acid levelsSimilar plasma glucose levelsFree fatty acid levelsCerebral glucose metabolismPlasma glucose levelsBrain glucose levelsFatty acid levelsAltered feeding behaviorGlucose incrementHyperglycemic clampBrain glucoseCerebral functionLean participantsOccipital lobeRodent modelsGlucose metabolismObesityT2DMGlucose responseHyperglycemiaNeurocognitive consequencesSimilar findingsAcid levelsIntracerebral glucose