2019
In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir
Kim J, Lam W, Wang Q, Parikh L, Elshafie A, Sanchez-Rangel E, Schmidt C, Li F, Hwang J, Belfort-DeAguiar R. In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 3911-3919. PMID: 31087061, PMCID: PMC6667277, DOI: 10.1210/jc.2019-00240.Peer-Reviewed Original ResearchFood intakeGlucose levelsNW individualsOB individualsPremeal glucoseCGM glucose levelsNormal-weight individualsBlood glucose levelsContinuous glucose-monitoring systemGreater food intakeInterstitial glucose levelsGlucose-monitoring systemGlucose nadirsWeight individualsGlucose profilesObeseFood logsEffect of glucoseHealthy individualsFree-Living SettingsIntakePostprandial ratesObesityLevel stimuliPredictive effect
2018
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia
Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Journal Of Clinical Investigation 2018, 128: 1485-1495. PMID: 29381484, PMCID: PMC5873861, DOI: 10.1172/jci97696.Peer-Reviewed Original ResearchConceptsMild hypoglycemiaHypoglycemia awarenessType 1 diabetes mellitus patientsPrefrontal cortexHormonal counterregulatory responsesDiabetes mellitus patientsImpaired hypoglycemia awarenessAltered activation patternsAngular gyrusType 1 diabetesBlood glucose levelsHypoglycemia-induced changesBrain responsesBrain activityHypoglycemia symptom scoresAlters brain activityClinical Translational Science AwardsHyperinsulinemic euglycemicHypoglycemia unawarenessCounterregulatory responsesHypoglycemic clampMellitus patientsMRI brainSymptom scoresNondiabetic individuals