Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma
Choi YJ, M Pinto M, Hao L, K Riba A. Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. Modern Pathology 2008, 21: 1224-1237. PMID: 18587329, DOI: 10.1038/modpathol.2008.106.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCadherinsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularDiagnosis, DifferentialFemaleHumansMiddle AgedObserver VariationReproducibility of ResultsConceptsE-cadherin stainingLobular carcinomaLobular neoplasiaDuct lesionsDuct carcinomaPrevious diagnosisBreast lesionsMorphologic diagnosisInterobserver variabilityDifferent antibodiesE-cadherinImportant therapeutic implicationsParaffin-embedded sectionsLoss of stainingE-cadherin staining patternDuctal neoplasiaDuctal lesionsHistologic featuresLobular lesionsHistology diagnosisSurgical pathologistsImmunohistochemistry techniquesTherapeutic implicationsBlinded mannerCarcinoma