Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination
Thakral D, Dobbins J, Devine L, Kavathas PB. Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination. The Journal Of Immunology 2008, 180: 7431-7442. PMID: 18490743, DOI: 10.4049/jimmunol.180.11.7431.Peer-Reviewed Original ResearchConceptsCytoplasmic tailSplice variantsExpression patternsCell surfaceDifferent cytoplasmic tailsGene splice variantsMRNA expression patternsMRNA levelsFluorescent chimerasHuman genesHuman lineageDifferential mRNA expression patternsHeterodimer functionsExtracellular domainLysine residuesQuantitative RT-PCRDifferential expressionLysosomal compartmentTCR complexFunctional significanceIsoformsCD8B geneUbiquitinationCell linesPrimary humanDifferential Expression of Human CD8 Beta‐chain Isoforms and Regulation of M‐2 Isoform (splice variant 1) by Ubiquitination
Thakral D, Dobbins J, Devine L, Kavathas P. Differential Expression of Human CD8 Beta‐chain Isoforms and Regulation of M‐2 Isoform (splice variant 1) by Ubiquitination. The FASEB Journal 2008, 22: 367-367. DOI: 10.1096/fasebj.22.2_supplement.367.Peer-Reviewed Original ResearchCytoplasmic tailCell surfaceDifferent cytoplasmic tailsMRNA expression patternsMurine geneMRNA levelsFluorescent chimerasDifferential mRNA expression patternsExpression patternsExtracellular domainQuantitative RT-PCRDifferential expressionLysine residuesDifferential regulationUbiquitinationLysosomal compartmentSplice variantsTCR complexIsoformsT cell receptorPrimary human CD8CD8B geneMRNA patternsCell linesGenes