2016
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno M, Gulden FO, Pochareddy S, Tebbenkamp AT, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 2016, 16: 2576-2592. PMID: 27568284, PMCID: PMC5135012, DOI: 10.1016/j.celrep.2016.08.038.Peer-Reviewed Original ResearchMeSH KeywordsAxl Receptor Tyrosine KinaseBrainCell DeathCentrosomeFetusGene Expression ProfilingHumansImmunity, InnateMicrocephalyMitochondriaMitosisNeocortexNeural Stem CellsNeuroepithelial CellsNeurogliaNeuronsNeuroprotective AgentsNucleosidesPhosphorylationProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSpinal CordTranscription, GeneticVirus ReplicationZika VirusZika Virus InfectionConceptsRadial glial cellsNES cellsNeuroepithelial stem cellsZIKV infectionFetal brain slicesStem cellsEarly human neurodevelopmentHuman neuroepithelial stem cellsHuman neural stem cellsCell deathSingle-cell RNA-seqNeural stem cellsNeurodevelopment defectsZIKV replicationGlial cellsBrain slicesPotential treatmentRadial gliaZika virusPhospho-TBK1Neurodevelopmental defectsRNA-seqSupernumerary centrosomesNucleoside analoguesHuman neurodevelopment
2002
Endogenous parathyroid hormone-related protein functions as a neuroprotective agent
Chatterjee O, Nakchbandi IA, Philbrick WM, Dreyer BE, Zhang J, Kaczmarek LK, Brines ML, Broadus AE. Endogenous parathyroid hormone-related protein functions as a neuroprotective agent. Brain Research 2002, 930: 58-66. PMID: 11879796, DOI: 10.1016/s0006-8993(01)03407-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCalcium ChannelsCells, CulturedCerebral CortexDose-Response Relationship, DrugExcitatory Amino Acid AgonistsFemaleInjections, IntraperitonealKainic AcidL-Lactate DehydrogenaseMiceMice, KnockoutNeuroblastomaNeuronsNeuroprotective AgentsParathyroid Hormone-Related ProteinPatch-Clamp TechniquesPregnancyProteinsConceptsL-type voltage-sensitive calcium channelsCalcium channelsHippocampal c-Fos expressionVoltage-sensitive calcium channelsKainic acid-induced excitotoxicityCerebral cortical culturesFunction of PTHrPKainic acid excitotoxicityL-type calcium channelsCultured cerebellar granule cellsSensitive calcium channelsHormone-related proteinCentral nervous systemWhole-cell techniqueC-fos expressionCultured mouse neuroblastoma cellsCerebellar granule cellsMouse neuroblastoma cellsKainate toxicityCerebral cortexNeuroprotective agentsKainic acidLittermate miceCortical culturesPTHrP functions