2002
Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons
Zhang Y, Magoski NS, Kaczmarek LK. Prolonged Activation of Ca2+-Activated K+Current Contributes to the Long-Lasting Refractory Period ofAplysia Bag Cell Neurons. Journal Of Neuroscience 2002, 22: 10134-10141. PMID: 12451114, PMCID: PMC6758731, DOI: 10.1523/jneurosci.22-23-10134.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalciumCells, CulturedElectric StimulationEnzyme ActivatorsEnzyme InhibitorsLarge-Conductance Calcium-Activated Potassium ChannelsNeural InhibitionNeuronsPatch-Clamp TechniquesPhloretinPotassiumPotassium Channel BlockersPotassium Channels, Calcium-ActivatedProtein Kinase CRefractory Period, ElectrophysiologicalSphingosineTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsRefractory periodBK currentsProtein kinase COnset of afterdischargeBK channel activityApplication of phloretinBK channel activatorsProlonged refractory periodAbility of stimulationRole of Ca2Blocker paxillinePharmacological characteristicsChannel activatorIntracellular Ca2Prolonged increaseOutward currentsInhibitor of PKCAfterdischargesNeuronsAdditional stimulationProlonged activationActivator of PKCChannel activity
1993
The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances
Fisher T, Lin C, Kaczmarek L. The peptide FMRFa terminates a discharge in Aplysia bag cell neurons by modulating calcium, potassium, and chloride conductances. Journal Of Neurophysiology 1993, 69: 2164-2173. PMID: 7688803, DOI: 10.1152/jn.1993.69.6.2164.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalcium ChannelsCells, CulturedChloride ChannelsElectric StimulationElectrophysiologyFMRFamideGangliaImmunohistochemistryIon ChannelsMembrane PotentialsMembrane ProteinsNeuritesNeuronsNeuropeptidesNeurotransmitter AgentsPotassium ChannelsStereotyped BehaviorTetradecanoylphorbol AcetateConceptsBag cell neuronsCell neuronsAction potentialsElectrical stimulationVoltage-activated calcium currentsOnset of afterdischargePowerful inhibitory influenceIntact abdominal gangliaIon substitution experimentsVoltage-clamp experimentsAfferent nervesProtein kinase C. 5Channel blockersCalcium currentPrimary cell culturesAbdominal ganglionInhibitory influenceAfterdischargesCyclic AMP analogueFMRFaOutward currentsNeuronal processesNeuronsAplysia bag cell neuronsReversal potential
1985
Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia
DeRiemer S, Schweitzer B, Kaczmarek L. Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia. Brain Research 1985, 340: 175-180. PMID: 4027644, DOI: 10.1016/0006-8993(85)90790-5.Peer-Reviewed Original ResearchConceptsBag cell neuronsCalcium-dependent enzymesCell neuronsNeuroactive peptidesAttenuation of secretionOnset of afterdischargeBrief electrical stimulationPeptidergic bag cell neuronsAbility of stimulationEffect of TFPEffects of agentsNeuronal excitabilitySynaptic transmissionAfterdischargesNeurosecretory neuronsElectrical stimulationEndogenous burstingNeuronsSecretionCalmodulin-dependent enzymesProtein kinaseAplysiaStimulationOnsetAgents
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons
1983
Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia
Kaczmarek L, Kauer J. Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia. Journal Of Neuroscience 1983, 3: 2230-2239. PMID: 6631477, PMCID: PMC6564640, DOI: 10.1523/jneurosci.03-11-02230.1983.Peer-Reviewed Original ResearchConceptsOnset of afterdischargeProlonged refractory periodBag cell clustersBag cell neuronsCumulative depolarizationRefractory periodNatural refractorinessCell neuronsCalcium entryAction potentialsConcentration of ionophoreExtracellular tetraethylammonium ionsRepetitive intracellular stimulationPeptidergic bag cell neuronsPleuroabdominal connectivesCell clustersCalcium-deficient mediumAdenylate cyclase activatorCalcium-containing mediumMean durationPeptidergic neuronsAbdominal ganglionAfterdischargesBrief trainsIntracellular stimulation