2014
More Than a Pore: Ion Channel Signaling Complexes
Lee A, Fakler B, Kaczmarek LK, Isom LL. More Than a Pore: Ion Channel Signaling Complexes. Journal Of Neuroscience 2014, 34: 15159-15169. PMID: 25392484, PMCID: PMC4228125, DOI: 10.1523/jneurosci.3275-14.2014.Peer-Reviewed Original ResearchConceptsIon channelsHeterologous expression systemIon channel complexSignaling ComplexFunctional dissectionHuman genomeMolecular basisExpression systemSecond messengerHuman diseasesChannel complexCellular excitabilityProteinNew insightsSuch interactionsInteractomeGenomeUnexpected propertiesComplexesMessengerPathwayInteractionDysregulationLocalizationVivo
2001
Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel
White B, Osterwalder T, Yoon K, Joiner W, Whim M, Kaczmarek L, Keshishian H. Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel. Neuron 2001, 31: 699-711. PMID: 11567611, DOI: 10.1016/s0896-6273(01)00415-9.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBehavior, AnimalCells, CulturedDrosophila melanogasterDrosophila ProteinsFemaleGene DosageGene Expression Regulation, DevelopmentalGene TargetingGenes, LethalLarvaMembrane PotentialsMusclesMutationNervous SystemNeural InhibitionNeuronsNeurons, AfferentPhenotypePhotoreceptor Cells, InvertebratePotassium ChannelsShaker Superfamily of Potassium ChannelsSynaptic TransmissionTransgenes
1987
Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancy
Boyle M, MacLusky N, Naftolin F, Kaczmarek L. Hormonal regulation of K+-channel messenger RNA in rat myometrium during oestrus cycle and in pregnancy. Nature 1987, 330: 373-375. PMID: 2446134, DOI: 10.1038/330373a0.Peer-Reviewed Original ResearchConceptsChannel messenger RNAUterine smooth muscle cellsSmooth muscle excitabilityEnd of pregnancyPresence of estrogenSmooth muscle cellsIon channelsEstrogen altersPregnant ratsHormonal treatmentMyometrial cellsRat myometriumSteroid hormonesMuscle cellsOestrous cycleCellular excitabilityOestrus cycleVoltage-dependent ion channelsHormonal regulationPregnancyEstrogenExcitabilityElectrical couplingMessenger RNAMessenger RNA species