1998
Protein Kinase C Regulates a Vesicular Class of Calcium Channels in the Bag Cell Neurons of Aplysia
White B, Nick T, Carew T, Kaczmarek L. Protein Kinase C Regulates a Vesicular Class of Calcium Channels in the Bag Cell Neurons of Aplysia. Journal Of Neurophysiology 1998, 80: 2514-2520. PMID: 9819259, DOI: 10.1152/jn.1998.80.5.2514.Peer-Reviewed Original Research
1997
Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californica
White B, Kaczmarek L. Identification of a Vesicular Pool of Calcium Channels in the Bag Cell Neurons of Aplysia californica. Journal Of Neuroscience 1997, 17: 1582-1595. PMID: 9030618, PMCID: PMC6573390, DOI: 10.1523/jneurosci.17-05-01582.1997.Peer-Reviewed Original ResearchConceptsBag cell neuronsCalcium channel alpha1 subunitAplysia nervous systemProtein kinase CCell neuronsAplysia californicaBag cell clustersCalcium channelsChannel alpha1 subunitCell clustersVesicular channelsMembrane proteinsReverse-transcribed RNAVesicular localizationPlasma membraneEgg-laying hormoneMolecular mechanismsSubcellular distributionKinase CLysoTracker RedDense-core vesiclesAcidic organellesGrowth conesCalcium channel subtypesCalcium current modulation
1990
Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia
Azhderian E, Kaczmarek L. Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia. Journal Of Molecular Neuroscience 1990, 2: 61-70. PMID: 1964064, DOI: 10.1007/bf02876912.Peer-Reviewed Original ResearchConceptsBag cell neuronsEgg-laying hormoneCell neuronsCAMP levelsPresence of tetrodotoxinBag cell clustersAdenylate cyclase activator forskolinELH prohormoneCyclase activator forskolinElevation of cAMPMembrane-permeant cAMP analogAbdominal ganglionControl clustersPermeant cAMP analogueAction potentialsNeuroactive peptidesTreatment of cellsProtein synthesis inhibitor anisomycinActivator forskolinNeuronsProhormoneAfterdischargesCyclic AMPTetrodotoxinComparative peptide mapping
1987
Alpha bag cell peptide directly modulates the excitability of the neurons that release it
Kauer J, Fisher T, Kaczmarek L. Alpha bag cell peptide directly modulates the excitability of the neurons that release it. Journal Of Neuroscience 1987, 7: 3623-3632. PMID: 2824716, PMCID: PMC6569037, DOI: 10.1523/jneurosci.07-11-03623.1987.Peer-Reviewed Original ResearchConceptsAlpha-bag cell peptideBag cell neuronsAlpha-BCPCell neuronsBag cell peptidesPotassium currentCell peptidesVoltage-dependent potassium currentsCAMP levelsVoltage-dependent outward currentIntact abdominal gangliaBag cell clustersAdenylate cyclase activator forskolinAbility of forskolinCyclase activator forskolinLevels of cAMPVoltage-clamp experimentsElectrophysiological actionsIntracellular cAMP levelsImmunohistochemical stainingIntact gangliaAbdominal ganglionPhosphodiesterase inhibitorPharmacological elevationOutward currents
1985
Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system
DeRiemer SA, Greengard P, Kaczmarek LK. Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system. Journal Of Neuroscience 1985, 5: 2672-2676. PMID: 4045549, PMCID: PMC6565129, DOI: 10.1523/jneurosci.05-10-02672.1985.Peer-Reviewed Original ResearchConceptsProtein kinase CProtein kinase activityAplysia nervous systemBag cell neuronsKinase CProtein phosphorylationKinase activityDiacylglycerol-dependent protein kinaseEndogenous substrate proteinsEndogenous enzymesCytosolic fractionTumor-promoting phorbol diestersCell neuronsSubstrate proteinsCell clustersBag cell clustersProtein kinaseDalton proteinMammalian tissuesSpecific substratesNervous systemPhosphorylationBovine brainMammalian brainPolymixin B sulfate
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons
1983
Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia
Kaczmarek L, Kauer J. Calcium entry causes a prolonged refractory period in peptidergic neurons of Aplysia. Journal Of Neuroscience 1983, 3: 2230-2239. PMID: 6631477, PMCID: PMC6564640, DOI: 10.1523/jneurosci.03-11-02230.1983.Peer-Reviewed Original ResearchConceptsOnset of afterdischargeProlonged refractory periodBag cell clustersBag cell neuronsCumulative depolarizationRefractory periodNatural refractorinessCell neuronsCalcium entryAction potentialsConcentration of ionophoreExtracellular tetraethylammonium ionsRepetitive intracellular stimulationPeptidergic bag cell neuronsPleuroabdominal connectivesCell clustersCalcium-deficient mediumAdenylate cyclase activatorCalcium-containing mediumMean durationPeptidergic neuronsAbdominal ganglionAfterdischargesBrief trainsIntracellular stimulation
1979
The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture
Kaczmarek L, Finbow M, Revel J, Strumwasser F. The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture. Developmental Neurobiology 1979, 10: 535-550. PMID: 521813, DOI: 10.1002/neu.480100604.Peer-Reviewed Original ResearchConceptsBag cell clustersBag cellsAbdominal ganglionLucifer YellowConnective tissueBag cell afterdischargeCell clustersSynchronous action potentialsIntracellular injectionIntact gangliaAction potentialsGangliaPrimary culturesNeurosecretory cellsDistal processesInjected cellsAfterdischargesCell actionGap junctionsSomaDye transferCellsPairs of cellsCell culturesCell processes
1978
Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites
Kaczmarek L, Jennings K, Strumwasser F. Neurotransmitter modulation, phosphodiesterase inhibitor effects, and cyclic AMP correlates of afterdischarge in peptidergic neurites. Proceedings Of The National Academy Of Sciences Of The United States Of America 1978, 75: 5200-5204. PMID: 217016, PMCID: PMC336293, DOI: 10.1073/pnas.75.10.5200.Peer-Reviewed Original Research