Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
Sun J, Zhang Y, Zhang Q, Hu L, Zhao L, Wang H, Yuan Y, Niu H, Wang D, Zhang H, Liu J, Feng X, Su X, Qiu J, Sun J, Xu H, Zhang C, Wang K, Bi Y, Engleman E, Shen L. Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. Immunity 2024, 57: 1289-1305.e9. PMID: 38772366, DOI: 10.1016/j.immuni.2024.04.024.Peer-Reviewed Original ResearchLiver kinase B1PD-1 expressionLKB1 deficiencyInsulin resistanceSuppressing Bcl-xL expressionBcl-xL expressionGroup 2 innate lymphoid cellsBlockade of PD-1Treatment of metabolic diseasesObesity-induced insulin resistanceFunction of ILC2sType 2 immunityMitochondrial homeostasisActivation of NFATObesity-associated insulin resistanceMitochondrial metabolismPrevent insulin resistanceKinase B1Exacerbate insulin resistanceEnhanced mitophagyMetabolic homeostasisILC2 responsesPD-1Genetic ablationLymphoid cellsLKB1 prevents ILC2 exhaustion to enhance antitumor immunity
Niu H, Zhang H, Wang D, Zhao L, Zhang Y, Zhou W, Zhang J, Su X, Sun J, Su B, Qiu J, Shen L. LKB1 prevents ILC2 exhaustion to enhance antitumor immunity. Cell Reports 2024, 43: 113579. PMID: 38670109, DOI: 10.1016/j.celrep.2023.113579.Peer-Reviewed Original ResearchAntitumor immunityPD-1Tumor immunityExpression of programmed cell death protein 1Group 2 innate lymphoid cellsBlockade of PD-1Cell death protein 1Lung melanoma metastasesAntitumor immune responseRegulating tumor immunityNuclear factor of activating T cells pathwayT-cell pathwayLiver kinase B1ILC2 functionMelanoma metastasesILC2sLymphoid cellsAllergic inflammationImmune homeostasisEffector functionsInactivating mutationsImmune responseHuman cancersCell pathwaysProtein 1