Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis
Wang H, Du Y, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L, Bi Y. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis. Nature Communications 2024, 15: 4827. PMID: 38844451, PMCID: PMC11156882, DOI: 10.1038/s41467-024-48914-w.Peer-Reviewed Original ResearchConceptsAdipose progenitor cellsT2D patientsProgenitor cellsDiphtheria toxin A expressionHeterogeneous stromal cellsGlycemic disturbancesAdipose tissueInfluence of obesityGlucose homeostasisVisceral adipose tissueHuman visceral adipose tissueImpaired glucose homeostasisType 2 diabetesHunter-killer peptidesRegulating glucose homeostasisSingle-cell analysisAPC functionStromal cellsA expressionMetabolic homeostasisAdipocyte lipolysisT2D developmentPatientsT2DBioactive proteinsMetabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
Sun J, Zhang Y, Zhang Q, Hu L, Zhao L, Wang H, Yuan Y, Niu H, Wang D, Zhang H, Liu J, Feng X, Su X, Qiu J, Sun J, Xu H, Zhang C, Wang K, Bi Y, Engleman E, Shen L. Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. Immunity 2024, 57: 1289-1305.e9. PMID: 38772366, DOI: 10.1016/j.immuni.2024.04.024.Peer-Reviewed Original ResearchLiver kinase B1PD-1 expressionLKB1 deficiencyInsulin resistanceSuppressing Bcl-xL expressionBcl-xL expressionGroup 2 innate lymphoid cellsBlockade of PD-1Treatment of metabolic diseasesObesity-induced insulin resistanceFunction of ILC2sType 2 immunityMitochondrial homeostasisActivation of NFATObesity-associated insulin resistanceMitochondrial metabolismPrevent insulin resistanceKinase B1Exacerbate insulin resistanceEnhanced mitophagyMetabolic homeostasisILC2 responsesPD-1Genetic ablationLymphoid cells