Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production
Su X, Zhao L, Zhang H, Wang D, Sun J, Shen L. Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 production. Frontiers In Immunology 2024, 15: 1402834. PMID: 39253083, PMCID: PMC11381250, DOI: 10.3389/fimmu.2024.1402834.Peer-Reviewed Original ResearchCitrobacter rodentium infectionIL-22 productionSirtuin 6Regulating gut immune responsesNicotinamide adenine dinucleotide (NAD+)-dependent deacetylaseDextran sodium sulfate-induced colitis modelIntestinal epithelial cell differentiationGroup 3 innate lymphoid cellsDextran sodium sulfate-induced colitisEpithelial cell differentiationGut immune responseFlow cytometryEpigenetic regulationIncreased IL-22 productionCell-intrinsic mannerDependent deacetylaseIntestinal ILC3sCell numberIntestinal inflammatory responseLymphoid cell functionGut defenseConditional knockout miceGut immunityIL-22 expressionHost defense