2019
Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy
Inohara T, Liang L, Kosinski A, Smith E, Schwamm L, Hernandez A, Bhatt D, Fonarow G, Peterson E, Xian Y. Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy. Journal Of The American Heart Association 2019, 8: e012450. PMID: 31327296, PMCID: PMC6761665, DOI: 10.1161/jaha.119.012450.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorRecent myocardial infarctionAcute ischemic strokeHistory of MIRisk of mortalityMyocardial infarctionAIS patientsIschemic strokeIntravenous recombinant tissue-type plasminogen activatorST-segment elevation myocardial infarctionSegment elevation myocardial infarctionMultivariate logistic regression modelGuidelines-Stroke hospitalsOnly medical therapyElevation myocardial infarctionTissue-type plasminogen activatorLogistic regression modelsHospital mortalityHospital outcomesSevere strokeMedical therapyThrombolytic therapyHigh riskInfarctionPatients
2014
Authors' Reply
Cavender M, Rassi A, Schwamm L, Fonarow G, Cannon C, Peacock W, Laskey W, Hernandez A, Peterson E, Cox M, Grau‐Sepulveda M, Bhatt D. Authors' Reply. Clinical Cardiology 2014, 37: 323-323. PMID: 24596074, PMCID: PMC6649478, DOI: 10.1002/clc.22265.Peer-Reviewed Original Research
2013
Relationship of Race/Ethnicity With Door‐to‐Balloon Time and Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST‐Elevation Myocardial Infarction: Findings From Get With the Guidelines–Coronary Artery Disease
Cavender M, Rassi A, Fonarow G, Cannon C, Peacock W, Laskey W, Hernandez A, Peterson E, Cox M, Grau‐Sepulveda M, Schwamm L, Bhatt D. Relationship of Race/Ethnicity With Door‐to‐Balloon Time and Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST‐Elevation Myocardial Infarction: Findings From Get With the Guidelines–Coronary Artery Disease. Clinical Cardiology 2013, 36: 749-756. PMID: 24085713, PMCID: PMC6649362, DOI: 10.1002/clc.22213.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack or African AmericanChi-Square DistributionFemaleGuideline AdherenceHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHospital MortalityHumansLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPercutaneous Coronary InterventionPractice Guidelines as TopicProspective StudiesRegistriesRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesWhite PeopleConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionDTB timeMedian DTB timeRace/ethnicityPercutaneous coronary interventionCoronary interventionArtery diseaseBalloon timeMyocardial infarctionGuidelines-Coronary Artery DiseaseProportion of patientsAfrican American raceAfrican AmericansAfrican American femalesDifferent races/ethnicitiesHospital mortalityD2B timeHispanic patientsHispanic ethnicityLower oddsAmerican racePatientsCrude differences
2012
Temporal Trends and Predictors in the Use of Aldosterone Antagonists Post-Acute Myocardial Infarction
Rassi A, Cavender M, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Rosas S, Zhao X, Schwamm L, Bhatt D. Temporal Trends and Predictors in the Use of Aldosterone Antagonists Post-Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2012, 61: 35-40. PMID: 23137936, DOI: 10.1016/j.jacc.2012.08.1019.Peer-Reviewed Original ResearchMeSH KeywordsAgedDiabetes MellitusDrug PrescriptionsDrug UtilizationFemaleGuideline AdherenceHeart FailureHospital Bed CapacityHumansKidney DiseasesMaleMineralocorticoid Receptor AntagonistsMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationPatient DischargePractice Guidelines as TopicRegistriesSmokingStroke VolumeUnited StatesConceptsPost-acute myocardial infarctionAldosterone antagonist useAldosterone antagonist therapyAldosterone antagonistsEjection fractionAntagonist useEligible patientsAntagonist therapyHospital dischargeHeart failureMyocardial infarctionActual prescribing patternsGuideline-based therapyAbsence of contraindicationsHistory of diabetesPost-AMI patientsHigher ejection fractionAmerican Heart AssociationLarger hospital sizeCoronary revascularizationPrescribing patternsAMI patientsKidney dysfunctionPost-AMITobacco abuseGuideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction
Somma K, Bhatt D, Fonarow G, Cannon C, Cox M, Laskey W, Peacock W, Hernandez A, Peterson E, Schwamm L, Saxon L. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2012, 5: 654-661. PMID: 22949493, DOI: 10.1161/circoutcomes.111.963959.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiovascular AgentsChi-Square DistributionComorbidityCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionSTEMI patientsMedical therapyNSTEMI patientsMyocardial infarctionGuidelines-Coronary Artery Disease registryNon-ST segment elevation myocardial infarctionGuideline-based medical therapyPrior coronary artery diseaseSegment elevation myocardial infarctionLow-density lipoprotein levelsSegment elevation MISimilar medical therapyLipid-lowering medicationsCoronary artery diseaseST-segment elevationGWTG-CADMedical comorbiditiesDischarge medicationsGuideline adherenceArtery diseaseHeart failureAngiotensin receptorsElevation MIPredictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction
Kumbhani D, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Pan W, Schwamm L, Bhatt D, Committee and Investigators G. Predictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2012, 126: 74.e1-74.e9. PMID: 22925314, DOI: 10.1016/j.amjmed.2012.02.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionGuidelines-Coronary Artery Disease registryAcute myocardial infarction treatmentAdherence modelCertain high-risk populationsGuideline-recommended therapiesLogistic multivariable regression modelsHigh-risk populationGuideline-based carePredictors of adherenceQuality improvement interventionsMultivariable regression modelsMyocardial infarction treatmentEligible patientsHospital characteristicsWorse adherenceSummary scoresDisease RegistryInfarction treatmentPatientsImprovement interventionsGreater adherenceInfarctionAdherenceReperfusion Strategies and Quality of Care in 5339 Patients Age 80 Years or Older Presenting With ST‐Elevation Myocardial Infarction: Analysis from Get With The Guidelines‐Coronary Artery Disease
Medina H, Cannon C, Fonarow G, Grau‐Sepulveda M, Hernandez A, Peacock W, Laskey W, Peterson E, Schwamm L, Bhatt D, Committee and Investigators O. Reperfusion Strategies and Quality of Care in 5339 Patients Age 80 Years or Older Presenting With ST‐Elevation Myocardial Infarction: Analysis from Get With The Guidelines‐Coronary Artery Disease. Clinical Cardiology 2012, 35: 632-640. PMID: 22744844, PMCID: PMC6652419, DOI: 10.1002/clc.22036.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAngioplasty, Balloon, CoronaryAntihypertensive AgentsConfidence IntervalsCoronary Artery DiseaseFemaleFibrinolytic AgentsHospital MortalityHumansHypolipidemic AgentsMaleMyocardial InfarctionMyocardial ReperfusionOdds RatioPlatelet Aggregation InhibitorsPractice Guidelines as TopicQuality of Health CareRegistriesThrombolytic TherapyConceptsPrimary percutaneous coronary interventionHospital mortalityReperfusion strategyNR patientsPatient ageUse of PCIGuidelines-Coronary Artery Disease databaseGuidelines-Coronary Artery DiseasePatients age 80 yearsST-elevation myocardial infarctionLower body mass indexGWTG-CAD hospitalsMain reperfusion strategyProportion of patientsPercutaneous coronary interventionAge 80 yearsBody mass indexLength of stayEvidence-based therapiesQuality of carePPCI patientsUnderwent thrombolysisHospital outcomesOld presentingRenal insufficiencyQuality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program
Vasaiwala S, Cannon C, Fonarow G, Peacock W, Laskey W, Schwamm L, Liang L, Hernandez A, Peterson E, Rosas S, Bhatt D, Committee and Investigators G. Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program. Clinical Cardiology 2012, 35: 541-547. PMID: 22744797, PMCID: PMC6652568, DOI: 10.1002/clc.22021.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGuidelines-Coronary Artery Disease programChronic renal insufficiencyRenal insufficiencyGlomerular filtration rateRenal functionInpatient careAMI patientsKidney failureMyocardial infarctionDisease programsAMI performance measuresGuideline-recommended therapiesMild renal insufficiencyModerate renal insufficiencySevere renal dysfunctionNormal renal functionSevere renal insufficiencyAmerican Heart AssociationMultivariable regression analysisQuality of careHospital mortalityRenal dysfunctionPatient characteristicsAdjusted mortalityAge and Gender Differences in Quality of Care and Outcomes for Patients with ST-segment Elevation Myocardial Infarction
Bangalore S, Fonarow G, Peterson E, Hellkamp A, Hernandez A, Laskey W, Peacock W, Cannon C, Schwamm L, Bhatt D, Committee and Investigators G. Age and Gender Differences in Quality of Care and Outcomes for Patients with ST-segment Elevation Myocardial Infarction. The American Journal Of Medicine 2012, 125: 1000-1009. PMID: 22748404, DOI: 10.1016/j.amjmed.2011.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overCohort StudiesFemaleGuideline AdherenceHealthcare DisparitiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CarePractice Guidelines as TopicPrognosisQuality Indicators, Health CareRegistriesRisk FactorsSex FactorsUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionQuality of careYounger patientsMyocardial infarctionHospital outcomesOlder patientsST-segment elevation myocardial infarction casesGuidelines-Coronary Artery Disease registryTraditional cardiovascular risk factorsCoronary Artery Disease registryCardiovascular risk factorsAmerican Heart AssociationMyocardial infarction casesOlder counterpartsYounger cohortsTime trend analysisHospital mortalityHospital deathHeart AssociationRisk factorsWorse outcomesInfarction casesThrombolytic timeDisease RegistryCare and Outcomes of Asian-American Acute Myocardial Infarction Patients
Qian F, Ling F, Deedwania P, Hernandez A, Fonarow G, Cannon C, Peterson E, Peacock W, Kaltenbach L, Laskey W, Schwamm L, Bhatt D. Care and Outcomes of Asian-American Acute Myocardial Infarction Patients. Circulation Cardiovascular Quality And Outcomes 2012, 5: 126-133. PMID: 22235068, DOI: 10.1161/circoutcomes.111.961987.Peer-Reviewed Original ResearchConceptsGuidelines-Coronary Artery Disease programAcute myocardial infarctionAMI patientsDisease programsBalloon timeWhite patientsAcute myocardial infarction patientsAMI performance measuresDefect-free careHospital mortality rateEvidence-based careAmerican Heart AssociationMyocardial infarction patientsAsian American patientsUnited States CentersHospital mortalityCessation counselingUnadjusted mortalityHeart failureHeart AssociationInfarction patientsMyocardial infarctionHigh prevalenceClinical careMortality rate
2011
Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry. American Heart Journal 2011, 162: 988-995.e4. PMID: 22137071, DOI: 10.1016/j.ahj.2011.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHispanic or LatinoHospitalizationHumansMaleMiddle AgedMyocardial InfarctionQuality of Health CareRegistriesTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionHispanic patientsQuality of careHospital mortalityClinical profileEnzyme inhibitors/angiotensin receptor blockersGuidelines-Coronary Artery Disease registryGuideline-recommended therapiesAngiotensin receptor blockersLipid-lowering therapyLonger hospital stayHigh rateHospital outcomesHospital stayReceptor blockersClinical characteristicsMale predominanceThrombolysis timeΒ-blockersRegional differencesDisease RegistryPatientsInfarctionHispanicsComparison of Composite Measure Methodologies for Rewarding Quality of Care
Eapen Z, Fonarow G, Dai D, O'Brien S, Schwamm L, Cannon C, Heidenreich P, Bhatt D, Peterson E, Hernandez A. Comparison of Composite Measure Methodologies for Rewarding Quality of Care. Circulation Cardiovascular Quality And Outcomes 2011, 4: 610-618. PMID: 22010200, DOI: 10.1161/circoutcomes.111.961391.Peer-Reviewed Original ResearchConceptsReadmission ratesHospital rankingsRisk-standardized readmission ratesRisk-standardized mortality ratesOpportunity-based scoreAcute myocardial infarctionBottom quintileComposite scoreModest correlationQuality Improvement ProgramComposite measureCause mortalityNumber of hospitalsHealth care performanceMyocardial infarctionMortality rateHospitalCare performanceScoresSimilar changesMortalityQuintileObservational analysisComposite performance measure
2009
Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure
Heidenreich P, Lewis W, LaBresh K, Schwamm L, Fonarow G. Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure. American Heart Journal 2009, 158: 546-553. PMID: 19781413, DOI: 10.1016/j.ahj.2009.07.031.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureMyocardial infarctionProcess of careAdditional adjustmentGuideline programHeart failure mortalityRisk-adjusted mortalityAmerican Heart AssociationAcute myocardial infractionMI mortalityHeart AssociationHospital characteristicsMyocardial infractionLower riskHospitalMortalityMedicaid ServicesCareHigh levelsInfarctionCardiac processesMedicareFailureGWTG
2007
Development of Systems of Care for ST-Elevation Myocardial Infarction Patients
Nallamothu BK, Krumholz HM, Ko DT, LaBresh KA, Rathore S, Roe MT, Schwamm L. Development of Systems of Care for ST-Elevation Myocardial Infarction Patients. Circulation 2007, 116: e68-72. PMID: 17538036, DOI: 10.1161/circulationaha.107.184052.Peer-Reviewed Original Research
2006
Neuroanatomic correlates of stroke-related myocardial injury
Ay H, Koroshetz W, Benner T, Vangel M, Melinosky C, Arsava E, Ayata C, Zhu M, Schwamm L, Sorensen A. Neuroanatomic correlates of stroke-related myocardial injury. Neurology 2006, 66: 1325-1329. PMID: 16525122, DOI: 10.1212/01.wnl.0000206077.13705.6d.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBrain IschemiaCardiomyopathiesCase-Control StudiesCerebral CortexCerebral InfarctionDiffusion Magnetic Resonance ImagingFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedMyocardial InfarctionMyocardiumNecrosisParietal LobeSingle-Blind MethodSympathetic Nervous SystemTroponin TConceptsCTnT elevationMyocardial injuryIschemic strokeRight middle cerebral artery infarctionSerum cardiac troponin T levelsCardiac troponin T elevationBrain regionsMiddle cerebral artery infarctionCardiac troponin T levelsPrimary cardiac causeTroponin T elevationAcute ischemic strokeTroponin T levelsCerebral artery infarctionCoronary artery diseaseSex-matched patientsRight inferior parietal lobuleSpecific brain regionsInferior parietal lobuleFrequency of rightBrain infarctionCardiac causesInfarction volumeSymptom onsetArtery diseaseRisk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes–Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study
Smith E, Cannon C, Murphy S, Feske S, Schwamm L. Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes–Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study. American Heart Journal 2006, 151: 338-344. PMID: 16442896, DOI: 10.1016/j.ahj.2005.03.031.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAcute coronary syndromeHistory of hypertensionPrior ischemic strokeIschemic strokeCerebrovascular eventsIntracranial hemorrhageRisk factorsCoronary syndromeHistory of TIAUnstable Coronary Syndromes-ThrombolysisHemorrhagic cerebrovascular eventsPlacebo-controlled trialCoronary artery diseaseLong-term patientsSignificant excess riskIschemic attackStroke outcomeArtery diseaseCoronary angiographyOverall incidenceCerebrovascular diseaseExcess riskHeart ratePatients