2021
Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage
Jones F, Sanches P, Smith J, Zafar S, Blacker D, Hsu J, Schwamm L, Newhouse J, Westover M, Moura L. Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage. JAMA Neurology 2021, 78: 1128-1136. PMID: 34309642, PMCID: PMC8314179, DOI: 10.1001/jamaneurol.2021.2249.Peer-Reviewed Original ResearchConceptsEarly seizure prophylaxisSpontaneous intracerebral hemorrhageAdverse drug reactionsRisk-guided strategyLate seizuresLong-term therapyHigh riskSeizure prophylaxisPrimary prophylaxisIntracerebral hemorrhageLower riskLong-term adverse drug reactionsLow-risk patientsShort-term prophylaxisDecision analytical modelSecondary therapyProphylaxis strategiesDrug reactionsProphylaxisMAIN OUTCOMESeizuresPatientsClinical decisionTherapyAverage riskAnticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients
Jones F, Sanches P, Smith J, Zafar S, Hernandez-Diaz S, Blacker D, Hsu J, Schwamm L, Westover M, Moura L. Anticonvulsant Primary and Secondary Prophylaxis for Acute Ischemic Stroke Patients. Stroke 2021, 52: 2782-2791. PMID: 34126758, PMCID: PMC8384723, DOI: 10.1161/strokeaha.120.033299.Peer-Reviewed Original ResearchConceptsQuality-adjusted life expectancySecondary prophylaxisAdverse drug reactionsADR riskLate seizuresPrimary prophylaxisMale patientsFemale patientsLifetime riskLS riskAcute ischemic stroke hospitalizationsLong-term secondary prophylaxisAcute ischemic stroke patientsHigher ADR risksAcute ischemic strokeIschemic stroke patientsIschemic stroke hospitalizationsCommon clinical scenariosShort-term therapyAnticonvulsant prophylaxisLifetime prophylaxisPersistent seizuresSeizure prophylaxisEarly seizuresIschemic stroke
2020
Patterns of anticonvulsant use and adverse drug events in older adults
Moura L, Smith J, Yan Z, Blacker D, Schwamm L, Newhouse J, Hernandez‐Diaz S, Hsu J. Patterns of anticonvulsant use and adverse drug events in older adults. Pharmacoepidemiology And Drug Safety 2020, 30: 28-36. PMID: 33009718, PMCID: PMC7849867, DOI: 10.1002/pds.5139.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticonvulsantsCohort StudiesDrug-Related Side Effects and Adverse ReactionsEpilepsyHumansMedicareUnited StatesConceptsAdverse drug eventsElectronic health recordsIncident usersAnticonvulsant useDrug eventsMedicare beneficiariesRate of ADEsSeverity of ADEsSignificant adverse drug eventsEligible beneficiariesOlder adultsCohort of communityDuration of useRange of indicationsTraditional Medicare beneficiariesInverse probability weightsADE ratesMonotherapy usersSingle anticonvulsantAnticonvulsant therapyPain reliefCommon indicationOriginal cohortNervous systemOlder adult community
1996
Delayed radiation-induced bulbar palsy
Shapiro B, Rordorf G, Schwamm L, Preston D. Delayed radiation-induced bulbar palsy. Neurology 1996, 46: 1604-1606.. PMID: 8649557, DOI: 10.1212/wnl.46.6.1604.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBulbar Palsy, ProgressiveCachexiaCarcinomaCobalt RadioisotopesCranial Nerve InjuriesCranial NervesDeglutition DisordersDyspneaElectromyographyEnteral NutritionHumansMaleNasopharyngeal NeoplasmsNeck InjuriesNeck MusclesPneumonia, AspirationRadiation InjuriesRadioisotope TeletherapySpeech DisordersTime Factors