2018
Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission
El Husseini N, Fonarow G, Smith E, Ju C, Sheng S, Schwamm L, Hernandez A, Schulte P, Xian Y, Goldstein L. Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission. Stroke 2018, 49: 2896-2903. PMID: 30571413, PMCID: PMC6338440, DOI: 10.1161/strokeaha.118.022011.Peer-Reviewed Original ResearchConceptsPoststroke mortalityIschemic strokeDialysis statusHospital readmissionKidney functionPoststroke outcomesMultivariable Cox proportional hazards modelsCox proportional hazards modelService Medicare patientsGlomerular filtration rateHospital readmission ratesRisk stratification modelProportional hazards modelEGFR 15Guidelines-StrokeIndex hospitalizationPostdischarge mortalityEGFR 30EGFR 45Readmission ratesRehospitalization ratesCohort studyKidney diseaseFiltration rateIndependent association
2016
Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality
El Husseini N, Fonarow G, Smith E, Ju C, Schwamm L, Hernandez A, Schulte P, Xian Y, Goldstein L. Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality. Stroke 2016, 48: 327-334. PMID: 28034963, PMCID: PMC5268130, DOI: 10.1161/strokeaha.116.014601.Peer-Reviewed Original ResearchConceptsHospital mortalityDischarge dispositionEGFR 15Renal dysfunctionEGFR levelsMultivariable Cox proportional hazards modelsRenal Disease Study equationCox proportional hazards modelAcute ischemic strokeIn-Hospital MortalityIschemic stroke patientsGlomerular filtration rateModification of DietShort-term outcomesNinth Revision codesProportional hazards modelDemographic factorsGuidelines-StrokeCohort studyEGFR 30EGFR 45Ischemic strokeFrequent comorbiditiesTotal cohortStroke patients
2014
Chronic Kidney Disease and Bleeding Complications After Intravenous Thrombolytic Therapy for Acute Ischemic Stroke
Ovbiagele B, Smith E, Schwamm L, Grau-Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Chronic Kidney Disease and Bleeding Complications After Intravenous Thrombolytic Therapy for Acute Ischemic Stroke. Circulation Cardiovascular Quality And Outcomes 2014, 7: 929-935. PMID: 25249561, DOI: 10.1161/circoutcomes.114.001144.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedBrain IschemiaFemaleFibrinolytic AgentsFollow-Up StudiesGlomerular Filtration RateHemorrhageHospital MortalityHumansIncidenceInjections, IntravenousMaleOdds RatioRegistriesRenal Insufficiency, ChronicRetrospective StudiesThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorUnited StatesConceptsChronic kidney diseaseSerious systemic hemorrhageSymptomatic intracranial hemorrhagePresence of CKDIntravenous tissue-type plasminogen activatorIntracranial hemorrhageSystemic hemorrhageTissue-type plasminogen activatorKidney diseaseFunctional statusTissue-type plasminogen activator administrationPlasminogen activatorAdmission serum creatinineGuidelines-Stroke programIndependent functional statusIntravenous thrombolytic therapyPrimary end pointAcute ischemic strokeIschemic stroke patientsGlomerular filtration rateNormal kidney functionDischarge functional statusHigher unadjusted oddsTissue-type plasminogenHospital mortalityHospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes
Ovbiagele B, Schwamm L, Smith E, Grau-Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes. Journal Of Stroke And Cerebrovascular Diseases 2014, 23: 2265-2273. PMID: 25158677, DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.016.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNormal renal functionICH patientsClinical characteristicsRenal functionKidney diseaseCare patternsDeep venous thrombosis prophylaxisGuidelines-Stroke programGWTG-Stroke programVenous thrombosis prophylaxisThird of patientsGlomerular filtration rateHemorrhagic stroke patientsNormal kidney functionIntracerebral hemorrhage patientsSmoking cessation interventionHospital mortalityThrombosis prophylaxisHospital outcomesRenal dysfunctionRenal insufficiencyInpatient mortalityClinical outcomesComorbid conditionsPatterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease
Ovbiagele B, Schwamm L, Smith E, Grau‐Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Patterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease. Journal Of The American Heart Association 2014, 3: e000905. PMID: 24904017, PMCID: PMC4309090, DOI: 10.1161/jaha.114.000905.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseIschemic stroke patientsSevere renal dysfunctionGlomerular filtration rateStroke patientsRenal dysfunctionQuality of careKidney diseaseHospitalized ischemic stroke patientsGuideline-based therapyGuideline-recommended therapiesGuidelines-Stroke programGWTG-Stroke programStroke performance measuresHospital mortality rateNormal kidney functionHospital mortalityHospital prognosisInpatient mortalityIschemic strokeCare complianceKidney functionModerate dysfunctionKidney failureFiltration rate